This volume presents the evolution of the authors' ideas about estrogen action and its modulation by a new group of drugs called SERMs (Selective Estrogen Receptor Modulators). The pioneering SERMs - tamoxifen and raloxifene - are known to have saved the lives of millions of women around the world and improved the health of millions more. Estrogen is the central hormone of women's health and reproduction. The book is a journey through 40 years of discovery and success in advancing women's health, with the prospect of improved innovation through medicinal chemistry for the future.
Centennial Article Cancer Research 2009. A Century of Deciphering the Control Mechanisms of Sex Steroid Action in Breast and Prostate Cancer: The Origins of Targeted Therapy and Chemoprevention (V C Jordan); Diethylstilbestrol: The Pioneering Cancer Treatment and Tragedy in Reproductive Endocrinology (J Lewis-Wambi & V C Jordan); Contraception and Women's Health (V D Castracane & V C Jordan); Hormone Replacement Therapy and Women's Health (J Eng-Wong et al.); Induction of Ovulation by Non-Steroidal Antiestrogens (I Obiorah & V C Jordan); Clues About Estrogen and Antiestrogen Action from X-ray Crystallography (G Greene & V C Jordan); Co-Regulator Activity and Their Role in Selective Estrogen Receptor Modulator Action (C D Chien et al.); Role of Estrogen in Familial Breast Cancer (E Rosen & C Isaacs); An Advance with Aromatase Inhibitors (S Chumsri et al.); Adjuvant Antihormone Therapy (A Howell & V C Jordan); Pharmacogenomics of Tamoxifen (H Brauch & V C Jordan); Antihormone Drug Resistance (R Clarke & V C Jordan); Novel Selective Estrogen Receptor Modulators (S Sengupta & V C Jordan); Chemoprevention and Breast Cancer (T Powles et al.); Selective Androgen Receptor Modulators (C C Coss & J T Dalton); Emerging Principle: Selective Nuclear Receptor Modulators (P Fan & V Craig Jordan); Appendix 1: Scientific Survival Suggestions; Appendix 2: Decades of Discovery; Appendix 3: The "Tamoxifen Team" over a 30-year Period: An Account of Students Obtaining a PhD Degree (or MD as a Medical Science Researcher in the British System for Medical Doctors).