With the completion of human genome sequencing, human genetics is poised for major developments in functional genomics, molecular diagnostics, pathogenesis of complex multifactorial diseases and gene-based therapy. This book includes manuscripts from an international symposium on human genetics and gene therapy as well as articles written by a selection of young researchers in the Asia Pacific region who are actively involved in a diverse range of medical problems, including cancers, infections, hypertension and myopia. New technologies being developed in gene therapy, lab-on-chips and bioinformatics are reported. The book provides a snapshot of the diverse approaches and solutions being developed at the frontiers of human genetics. It will be useful to researchers and students in molecular genetics and the life sciences, professionals in the biotechnology and pharmaceutical industries, as well as clinicians who are interested in molecular medicine and gene therapy.
Part 1 Emerging technologies: FISH for the obstetrician and gynaecologist - a rapid and reliable tool aiding clinical analysis, L.A. Gole et al; silico biotech, P. Kanguene and M.K. Sakharkar; bioinformatics integration simplified - the Kleisli way, L.S. Wong; issues in secondary structure prediction quality, B. Cheng. Part 2 Genes and diseases: G6PD deficiency and application of the MPTP technique, P.S. Lai et al; analysis of deletion breakpoints in dystrophin transcripts, H.H. Khng et al; maple syrup urine disease - a report of 26 cases in the Philippines, C.D. Padilla et a; the heterogeneity of thalassaemia in Southeast Asia, S. Fucharoen and P. Winichagoon; genetics and susceptibility to tuberculosis - a review, E.M.C. Cutiongco; identification of RB1 gene mutations with constitutional origin, R. Rong et al. Part 3 Gene therapy: molecular medicine - potential therapies for genetic diseases, S.D. Wilton; development of HVJ-liposomes and cancer gene therapy, Y. Kaneda; naked plasmids -muscling into gene transfer, O.L. Kon et al; treatment of Duchenne muscular dystrophy at the mRNA level, M. Matsuo and Y. Takeshima; strategy of gene therapy for liver cirrhosis and liver cancer, J. Fujimoto. (Part contents).