This important volume commences with an overview of the modes of action of defensive secondary metabolites, followed by detailed surveys of chemical defense in marine ecosystems, the biochemistry of induced defense, plant-microbe interactions and medical applications. A chapter is also included covering biotechnological aspects of producing valuable secondary metabolites in plant cell and organ cultures. This is a comprehensive and fully updated new edition, edited by Professor Michael Wink and including contributions from many internationally acknowledged experts in the field.
Michael Wink is Professor of Pharmaceutical Biology and Director at the Institute of Pharmacy and Molecular Biotechnology (IPMB), Heidelberg University, Germany
List of contributors Preface 1 Introduction Michael Wink 1.1 Ecological function of secondary metabolites 1.2 Presence of defence and signal compounds at the right time and place 1.3 Molecular modes of action of SM 1.4 Biotechnology and utilization of SM 1.5 Conclusions 2 Molecular Modes of Action of Defensive Secondary Metabolites Michael Wink and Oskar Schimmer 2.1 Introduction 2.2 Molecular modes of action an overview 2.3 Accumulation of defence and signal compounds in plants 2.4 Animal responses: detoxification mechanisms and adaptations 2.5 Concluding remarks 3 Chemical Defence in Marine Ecosystems Annika Putz and Peter Proksch 3.1 Introduction 3.2 Marine natural products in allelopathic interactions 3.3 Chemical defence against fouling 3.4 Chemical defences of marine invertebrates and algae against consumers 3.5 Favoured allocation of defensive metabolites in vulnerable and valuable parts of marine invertebrates and algae 3.6 The flexible response: stress-induced accumulation of defence metabolites and activation of protoxins 3.7 Endosymbionts as sources for allelochemicals found in marine invertebrates 3.8 Conclusions and outlook 4 Plant Microbe Interactions and Secondary Metabolites with Antibacterial, Antifungal and Antiviral Properties Jurgen Reichling 4.1 Introduction 4.2 Phytoalexins 4.3 Antibacterial and antifungal agents of higher plants 4.4 Secondary metabolites from higher plants with antiviral properties 4.5 Conclusions 5 New Medical Applications of Plant Secondary Metabolites Jorg Heilmann 5.1 Introduction 5.2 Compounds with anticancer and chemopreventive activity 5.3 Antiviral compounds 5.4 Antimalarial drugs 5.5 Anti-inflammatory drugs 5.6 Antidepressant drugs 5.7 Anti-ischaemic drugs 5.8 Immunostimulatory drugs 5.9 Conclusions 6 Production of Natural Products by Plant Cell and Organ Cultures August-Wilhelm Alfermann 6.1 Introduction 6.2 Production of natural products by cell and organ cultures 6.3 Elicitation 6.4 Increase/decrease of product yields by genetic manipulation 6.5 Biosynthetic pathways delineation using RNA-interference 6.6 Mass cultivation of plant cell cultures 6.7 Production of recombinant proteins by plants and plant cell cultures 6.8 Production of plant natural products in microbes 6.9 Perspectives Index