Genome Stability: DNA Repair and Recombination

Genome Stability: DNA Repair and Recombination

By: James Haber (author)Paperback

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Genome Stability: DNA Repair and Recombination describes the various mechanisms of repairing DNA damage by recombination, most notably the repair of chromosomal breaks. The text presents a definitive history of the evolution of molecular models of DNA repair, emphasizing current research. The book introduces the central players in recombination. An overview of the four major pathways of homologous recombinational repair is followed by a description of the several mechanisms of nonhomologous end-joining. Designed as a textbook for advanced undergraduate and graduate students with a molecular biology and genetics background, researchers and practitioners, especially in cancer biology, will also appreciate the book as a reference.

About Author

James Haber is at Brandeis University, Biology Deptartment, USA.


Chapter 1: Restarting DNA Replication by Recombination Chapter 2. Double-strand Break Repair Pathways Chapter 3: RecA/Rad51 and the Search for Homology Chapter 4. Preparation of the RecA/Rad51 Filament Chapter 5. Single-Strand Annealing Chapter 6. Gene Conversion Chapter 7. In vivo Biochemistry: Recombination in Yeast Chapter 8: Break-induced Replication Chapter 9: Sister Chromatid Repair Chapter 10. Gene Targeting Chapter 11. Site-specific Recombination Chapter 12. Cytology and Genetics of Meiosis Chapter 13. Molecular Events During Meiotic Recombination Chapter 14 Holliday Junction Resolvases and Crossing-over Chapter 15. Nonhomologous End-joining Chapter 16. DNA Damage Checkpoints and Genome Instability

Product Details

  • ISBN13: 9780815344858
  • Format: Paperback
  • ID: 9780815344858
  • weight: 839
  • ISBN10: 0815344856

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