Thanks to the mircaulous Guru Guru Bone, Ponta the Labrador retriever can turn into a human girl - and she has found true love with Mirai Ikawa, who knows her secret but loves her just the same. But lately, the Guru Guru Bone hasn't been working very well, and dating has become ruff-ruff.
Gang, an aggressive Labrador, is drooling over Ponta, unaware that she's human half the time. And Gang's owner, Aoka, is attracted to Mirai, and will stop at nothing to have him for herself. When Aoka hatches a plan to 'marry' Gang and Ponta, she sets in motion a chain of events that may leave Ponta expecting puppies and Mirai all alone!