Following the familiar, easy-to-use at a Glance format, Haematology at a Glance, Fourth Edition is a broad and accessible introduction to the study of blood. Fully revised and updated to reflect advances in the field and in clinical practice, this new edition covers essential knowledge, from basic hematological physiology to blood disorders and their diagnosis and treatment. This new edition of Haematology at a Glance: Features expanded sections on the underlying mechanisms, diagnostic techniques and management of the malignant haematological diseases. Also incorporates recent advances in knowledge of thrombosis and the newer oral anticoagulants Contains the very latest clinical treatments Includes updated illustrations and clinical photographs to illustrate concepts and aid understanding Features extensive online self-assessment at www.ataglanceseries.com/haematology This book is an invaluable resource for medical students and health professionals wanting to consolidate and expand their knowledge of haematology.
About Author Atul B. Mehta and A. Victor Hoffbrand are both at the Royal Free and University College School of Medicine, Royal Free Hospital, London
Contents Preface to the fourth edition 6 Preface to the first edition 6 Glossary 7 Normal values 8 About the companion website 9 Part 1 Basic physiology and practice 1 Haemopoiesis: physiology and pathology 10 2 Normal blood cells I: red cells 14 3 Normal blood cells II: granulocytes, monocytes and the reticuloendothelial system 18 4 Normal blood cells III: lymphocytes 20 5 Lymph nodes, the lymphatic system and the spleen 23 6 Clinical assessment 24 7 Laboratory assessment 26 Part 2 Red cell disorders 8 General aspects of anaemia 30 9 Iron I: physiology and deficiency 33 10 Iron II: overload and sideroblastic anaemia 36 11 Megaloblastic anaemia I: vitamin B12 (B12) and folate deficiency biochemical basis, causes 38 12 Megaloblastic anaemia II: clinical features, treatment and other macrocytic anaemias 40 13 Haemolytic anaemias I: general 42 14 Haemolytic anaemias II: inherited membrane and enzyme defects 44 15 Haemolytic anaemias III: acquired 46 16 Haemolytic anaemias IV: genetic defects of haemoglobin thalassaemia 48 17 Haemolytic anaemias V: genetic defects of haemoglobin sickle cell disease 52 Part 3 Benign disorders of white cells 18 Benign disorders of white cells I: granulocytes, monocytes, macrophages 54 19 Benign disorders of white cells II: lymphocytes, lymph nodes, spleen, HIV 56 Part 4 Haematological malignancies 20 Introduction to Haematological malignancy: basic mechanisms 58 21 General aspects of treatment 61 22 Acute leukaemia I: classifi cation and diagnosis 64 23 Acute leukaemia II: treatment and prognosis 68 24 Chronic Myeloid Leukaemia (BCR-ABL1 positive) 70 25 Myelodysplasia (myelodysplastic syndromes) 72 26 Myeloproliferative disorders I: introduction 74 27 Myeloproliferative disorders II: polycythaemia rubra vera 76 28 Myeloproliferative disorders III: essential thrombocythaemia, primary myelofi brosis and systemic mastocytosis 78 29 Chronic lymphocytic leukaemia 80 30 Multiple myeloma and plasma cell disorders 83 31 Lymphoma I: introduction 86 32 Lymphoma II: Hodgkin lymphoma 88 33 Lymphoma III: non-Hodgkin lymphoma aetiology and classification 90 34 Lymphoma IV: clinical and laboratory features of more common subtypes 92 35 Lymphoma V: treatment and prognosis 94 Part 5 Treatment and procedures 36 Bone marrow failure 96 37 Haematological effects of drugs 98 38 Stem cell transplantation 100 Part 6 Haemostasis 39 Normal haemostasis I: vessel wall and platelets 102 40 Normal haemostasis II: coagulation factors and fi brinolysis 104 41 Disorders of haemostasis I: vessel wall and platelets 106 42 Disorders of haemostasis II: inherited disorders of coagulation 108 43 Disorders of haemostasis III: acquired disorders of coagulation 110 44 Thrombosis and anti-thrombotic therapy 112 45 Anticoagulation 115 Part 7 Haematological aspects of tropical disease 46 Haematological aspects of tropical diseases 118 47 Haematology of pregnancy and infancy 120 Part 8 Blood transfusion 48 Blood transfusion I 122 49 Blood transfusion II 124 Appendix: cluster of differentiation nomenclature system 127 Index 129
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