This authoritative handbook covers all aspects of immunosenescence, with contributions from experts in the research and clinical areas. It examines methods and models for studying immunosenescence; genetics; mechanisms including receptors and signal transduction; clinical relevance in disease states including infections, autoimmunity, cancer, metabolic syndrome, neurodegenerative diseases, frailty and osteoporosis; and much more.
Methods and Models for Studying Immunosenescence.- The Immune Risk Profile and Associated Parameters in Late Life: Lessons from the OCTO and NONA Longitudinal Studies.- Lymphocytes Sub-Types and Functions in Centenarians as Models for Successful Ageing.- Mouse Models and Genetics of Immunosenescence.- Insect Models of Immunosenescence.- Clonal Culture Models of T-cell Senescence.- Mouse Models of Influenza.- A Transgenic Dwarf Rat Strain as a Tool for the Study of Immunosenescence in Aging Rats and the Effect of Calorie Restriction.- Mathematical Modeling of Immunosenescence: Scenarios, Processes and Limitations.- Cellular Immunosenescene - T Cells.- Age, T-cell Homeostasis, and T-cell Diversity in Humans.- The Role of T-regulatory Cells in Immune Senescence.- Age-related Changes in Subpopulations of Peripheral Blood Lymphocytes in Healthy Japanese Population.- Age-associated T-cell Clonal Expansions (TCE) in vivo-Implications for Pathogen Resistance.- T-cell Cycle and Immunosenescence: Role of Aging in the T-cell Proliferative Behaviour and Status Quo Maintenance.- Mismatch Repair System and Aging: Microsatellite Instability in Peripheral Blood Cells of the Elderly and in the T-cell Clone Longitudinal Model.- Activation-Induced Cell Death of T-Cells in Elderly.- CD8 Clonal Expansions in Mice: An Age-associated Alteration of CD8 Memory T-cells.- Generation and Gene Expression of CD28-CD8 T-cells in Human.- Role of Regulatory Subsets During Aging.- Transcription Factors in Mature B-Cells During Aging.- B-Cell Repertoire Changes in Mouse Models of Aging.- B-Cells and Antibodies in Old Humans.- Neutrophil Granulocyte Functions in the Elderly.- Signal Transduction Changes in fMLP, TLRs, TREM-1 and GM-CSF Receptors in PMN with Aging.- Synergistic Effects of Ageing and Stress on Neutrophil Function.- Role of Dendritic Cells in Aging.- Phenotypic and Functional Changes of Circulating Monocytes in Elderly.- NK Cells in Human Ageing.- Natural Killer Cells and Human Longevity.- The Effects of Age on CD1d-restricted NKT-cells and Their Contribution to Peripheral T-cell Immunity.- Lympho-Hematopoietic Stem Cells and Their Aging.- Implications of Developmental Switches for Hematopoietic Stem Cell Aging.- Associations of Cytokine Polymorphisms with Immunosenescence.- Cytokine Polymorphisms and Immunosenescence.- Role of TLR Polymorphisms in Immunosenescence.- Mechanisms - Receptors and Signal Transduction.- Signal Transduction Changes in T-cells with Aging.- Molecular Signaling of CD95- and TNFR-Mediatedapoptosis in Naive and Various Memory Subsets of T-Cells.- Mitochondria and Immunosenescence.- Proteasome Activity and Immunosenescence.- Age-Related Changes in Type 1 and Type 2 Cytokine Production in Humans.- Cytokine Expression and Production Changes in Very Old Age.- Neuro-Endocrine-Immune Network and its Age-Related Changes.- Sex Hormones and Immunosenescence.- Glucocorticoids and DHEA: Do They Have a Role in Immunosenescence?.- Thymic Involution and Thymic Renewal.- Inflamm-Aging.- Molecular and Cellular Aspects of Macrophage Aging.- Clinical Relevance in Disease States-Infection.- Aging and HIV Disease: Synergistic Immunological Effects?.- Role of Immunosenescence in Infections and Sepsis in the Elderly.- Beneficial and Detrimental Manifestations of Age on CD8+ T-Cell Memory to Respiratory Pathogens.- HIV Infection as a Model of Accelerated Immunosenescence.- Autoimmunity and Autoimmune Diseases in the Elderly.- Autoimmunity-Aging Mouse Model for Autoimmune Diseases.- Atherosclerosis-An Age-dependent Autoimmune Disease.- Immuno-Inflammatory Athero-Arteriosclerosis Induced by Elastin Peptides. Effect of Age.- Aging, Immunity and Cancer.- Breast Cancer and Immunosenescence.- Aging, Cancer and Apoptosis in Animal Models and Clinical Settings.- Her-2/neu Transgenic Mice for Evaluation of Immune and Antitumor Responses Against Self-Tumor Antigens in the Young and the Old.- Cancer Immunotherapy and Aging: Lessons From the Mouse.- Insulin Resistance, Chronic Inflammation and the Link with Immunosenescence.- Decline of Immune Responsiveness: A Pathogenetic Factor in Alzheimer's Disease?.- Inflammatory Markers and Frailty.- CMV Infection and Frailty: Immunologic Consequences and Disease Pathogenesis.- Osteoporosis, Inflammation and Ageing.- Modulation- Nutrition.- Protein-Energy Malnutrition as a Determinant for Immuno-Senescence.- Role of Zinc and Selenium in Oxidative Stress and Immunosenescence: Implications for Healthy Ageing and Longevity.- Immunomoduation by Polyunsaturated Fatty Acids: Impact on T-cell Functions and Signaling.- Omega-3 Polyunsaturated Fatty Acids and Immunosenescence.- Effect of Intrinsic and Extrinsic Lipids on T-cell Signalling.- Effect of Anti-influenza Vaccination on Immune System in the Elderly.- Immunosenescence Modulation by Vaccination.- Interleukin -7 and Immunorejuvenation.- Assessment of Age-related Decline of Immunological Function and Possible Methods for Immunological Restoration in Elderly.- Thymic Regeneration in Mice and Humans Following Sex Steroid Ablation.- Nutraceuticals and Immune Restoration in the Elderly.- Gene Therapy and Immune Senescence.- Perspectives: Is Immunosenescence Clinically Relevant?.
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- ID: 9781402090622
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