This book meets the long-awaited need for a comprehensive overview of the biological role of HDLs. Edited by one of the pioneers in HDL and cholesterol research, this monograph summarizes current knowledge on HDL turnover, regulation and physiology. Clearly structured, the various sections cover HDL structure, formation, secretion and removal, as well as plasma metabolic factors. The biological activities and clinical aspects are equally discussed, as is the impact of HDL on common diseases and their prevention.
Christopher Fielding is Neider Professor of Cardiovascular Physiology at the University of California at San Francisco (UCSF). He graduated from University College in London (UK) where he also received his PhD. After appointments at Oxford University and at the University of Chicago, he joined the faculty at UCSF in 1971, being appointed full professor in 1985. Professor Fielding is a pioneer in the HDL field who developed many of the current concepts in HDL metabolism and its role in health and disease.
HDL STRUCTRE Apolipoprotein A1 Apolipoprotein A2 Apolipoprotein E Apolipoprotein M HDL PLASMA METABOLIC FACTORS ABC Transporters Apo A1 Recycling and LCAT CETP, PLTP and Enothelial Lipase Phospholipid Transfer Proteins HDL Remodelling by Lipases HDL FORMATION, SECRETION, REMOVAL Apo A1 Synthesis and Secretion Mouse Models of HDL Synthesis and Secretion Hepatic and Renal HDL Receptors BIOLOGICAL ACTIVITIES OF HDL HDL and Inflammation HDL and Exercise HDL and Endothelium Apo A1 and Nutrition Nutrition and HDL Speciation CLINICAL ASPECTS OF HDL HDL in Metabolic Syndromes HDL and Genetics HDL and Atherosclerosis HDL-raising Drugs