This volume has gathered some of the experts in the field to review aspects of our understanding of CMV and to offer perspectives of the current problems associated with CMV. The editors and authors hope that the chapters will lead to a better understanding of the virus that will assist in the development of new and unique antivirals, a protective vaccine, and a full understanding of CMV's involvement in human disease.
Forward.- 1. Human cytomegalovirus genome.- 2. Human cytomegalovirus microRNAs.- 3. Mutagenesis of the cytomegalovirus genome.- 4. Cytomegalovirus cell tropism.- 5. Cytomegalovirus entry and innate immune activation.- 6. Functions of human cytomegalovirus tegument proteins prior to immediate early gene.- expression.-7. Initiation of cytomegalovirus infection at ND10.- 8. Functional roles of the human cytomegalovirus essential IE86 protein.- 9. Nuts and bolts of human cytomegalovirus lytic DNA replication.- 10. Interactions of human cytomegalovirus proteins with the nuclear transport machinery.- 11. Structure and formation of the cytomegalovirus virion.- 12. Human cytomegalovirus modulation of signal transduction.- 13. Chemokines and chemokine receptors encoded by cytomegaloviruses.- 14. Subversion of cell cycle regulatory pathways by human cytomegalovirus.- 15. Modulation of host cell stress responses by human cytomegalovirus.- 16. Control of apoptosis by human cytomegalovirus.- 17. Aspects of human cytomegalovirus latency and reactivation.- 18. Murine model of cytomegalovirus latency and reactivation.- 19. Cytomegalovirus immune evasion.- 20. Cytomegalovirus vaccine development.- 21. Human cytomegalovirus infection in the developing placenta: maternal immunity and cytotrophoblast differentiation.- 22. Mechanisms of cytomegalovirus-accelerated vascular disease: induction of paracrine factors that promote angiogenesis and wound healing.- 23. Manifestations of human cytomegalovirus infection: proposed mechanisms of acute and chronic disease.-