The story of our evolutionary past is told in our genome sequence. Human Gene Evolution deals with the origins of human genes, describes their structure, function, organisation and expression. The text integrates our emerging knowledge of chromosome and genome structure, and discusses the nature of the mutational mechanisms underlying evolutionary change.
Part 1. Introduction and Overview. 1. Structure and Function in the Human Genomes. 2. Evolution of the Human Genomes. Part 2. Evolution of Gene Structure. 3. Introns, Exons and Evolution. 4. Genes and Gene Families. 5. Promoters and Transcriptions Factors. 6. Pseudigenes and their Formation. Part 3. Mutational Mechanisms in Evolution. 7. Single Base-pair Substitutions. 8. Contractions and Expansions in Gene Size and Number. 9. Genes and Rearrangements. 10. Molecular Reconstruction of Ancient Genes/Proteins.