This multivolume work is the only comprehensive, up-to-date reference work on the theory, occurrence and application of hydrogen transfer processes. Adopting an integrated approach, this handy reference includes essential information on the theoretical basis, the fundamental types, and the latest techniques used to reveal, monitor, as well as measure hydrogen transfer reactions. Renowned experts from a number of disciplines provide a thorough overview on all aspects of hydrogen transfer in natural and artificial systems, thus aiding readers in their own research. Numerous tables and illustrations facilitate fast and easy access to the desired information, making this an indispensable source of knowledge for every research group working in the field.
Professor Schowen has closed his research groups, but continues to work in collaborations. Active programs include these projects: - Studies of the mechanism, involvement of protein dynamics, and antiparasitic drug design for S-adenosylhomocysteine hydrolases - Studies of the stability and degradation kinetics and mechanisms of peptide and protein pharmaceuticals in solution and in solid-phase, polymeric solids - Design and characterization of green catalysts
PART 1 Prototropic rearrangements Hydrogen transfer in the gas phase Hydrogen transfer in liquids and solids Hydrogen isotope effects and transition-state structure Quantum theoretical treatments of hydrogen transfer Principles of hydrogen transfer in solution Multiple isotope effects as diagnostic tools of mechanism NMR Methods in the study of hydrogen transfer Hydrogen transfer in ice Hydrogen bonding and hydrogen transfer Hydrogen transfer in designed catalysts Hydrogen-atom transfer in solution PART 2 Proton transfer in solution reactions Theory of proton transfer in enzymic and model reactions Model reactions for enzymic hydride transfer Proton transfer in enzymic acid-base catalysis Proton conduction in enzyme action Hydrogen bonding and enzyme catalysis Prototropic rearrangements in enzymic systems Proton transfer in thiamin activation and other enzymic C-H fissions Proton transfer and protein folding Quantum tunneling in enzymic hydrogen transfer Hydrogen-atom transfer in enzymic systems Hydrogen transfer and protein stability