Hypertension: Methods and Protocols

Hypertension: Methods and Protocols

By: Jerome P. Fennell (author), Andrew H. Baker (author), Jerome P. Fennell (editor), Andrew H. Baker (editor)Hardback

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Modern molecular biology provides a bridge of understanding from the chemical through to the clinical, helping to reduce the risks of stroke, myocardial infarction, renal failure and cardiac failure. Hypertension: Methods and Protocols deals with animal models of hypertension, the methods of assessing the role of free radicals in hypertension that are applicable to all forms of endothelial dysfunction, methods that aid in the genetic dissection of hypertension, protein techniques, gene transfer, and the derivation of cardiomyocytes from embryonic stem cells.


Table of Contents; Hypertension: Methods and Protocols; Edited by Jerome Fennell and Andrew H. Baker; Preface; Contributors; Part I. Models of Hypertension; 1. Congenic/Consomic Models of Hypertension; Delyth Graham, Martin W. McBride, Nicholas JR Brain, and Anna F. Dominiczak; 2. Mouse Knockout Models of Hypertension; Michael Bader; 3. Production of Transgenic Models in Hypertension; Elena Popova, Michael Bader, and Alexander Krivokharchenko; 4. Measuring Blood Pressure in Small Laboratory Animals; Klaas Kramer and Rene Remie; Part II. Assessment of Free Radicals in Endothelial Dysfunction; 5. Analysis of Superoxide Anion Production in Tissue; Michela Zanetti, Livius V. d'Uscio, Timothy E. Peterson, Zvonimir S. Katusic, and Timothy O'Brien; 6. Measurement of Vascular Reactive Oxygen Species Production by Chemiluminescence; Tomasz J. Guzik and Keith M. Channon; 7. A Guide to Wire Myography; Angela Spiers and Neal Padmanabhan; Part III. Nucleic Acid Techniques; 8. Selection of Candidate Genes in Hypertension; Charles A. Mein, Mark J. Caulfield, and Patricia B. Munroe; 9. Genome Wide Scanning with SSLPs in the rat; Carol Moreno, Kathleen Kennedy, Jaime Wendt Andrae, and Howard J. Jacob; 10. Extraction of RNA from Cells and Tissue; Ian M. Bird; 11. Single Strand Conformational Polymorphism (SSCP) Analysis: Basic Principles and Routine Practice; Yanbin Dong and Haidong Zhu; 12. Single Nucleotide Polymorphism (SNP) Genotyping for Disease Association Studies; Myriam Fornage and Peter A. Doris; 13. Denaturing High-Performance Liquid Chromatography (DHPLC) Using the WAVE DNA Fragment Analysis System; Elizabeth Donohoe; 14. TaqMan Real-time PCR Quantification: Conventional and Modified Methods; Michihiro Yoshimura, Shota Nakamura, and Hisao Ogawa; 15. Generation of High Sensitivity Antisense cDNA Probes by Asymmetric PCR; Ian M. Bird; 16. New Advances in Microarrays: Finding the Genes Causally Involved in Disease; Claudio Napoli, Filomena de Nigris and Vincenzo Sica; 17. Pharmacogenetics and Pharmacogenomics; Klaus Lindpaintner; Part IV. Proteins and Proteomics; 18. Determination of the Endogenous Nitric Oxide Synthase Inhibitor Asymmetric Dimethylarginine in Biological Samples by HPLC; Tom Teerlink; 19. Proteomic Approaches in the Analysis of Hypertension; Soren Naaby-Hansen, Gayathri D Warnasuriya, Claire Hastie, and Rainer Cramer; Part V. Gene Transfer; 20. Gene Transfer in Endothelial Dysfunction and Hypertension; Ssabya Sen, Padraig M. Strappe, and Timothy O'Brien; 21. Non-viral Gene Delivery Methods in Cardiovascular Diseases; Marika Ruponen, Zanna Hyvonen, Arto Urtti, and Seppo Yla-Herttuala.

Product Details

  • ISBN13: 9781592598502
  • Format: Hardback
  • Number Of Pages: 425
  • ID: 9781592598502
  • ISBN10: 1592598501

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