A vast number of neural cell surface glycoproteins belonging to the immunoglobulin superfamily have been isolated over the past two decades. In functional studies, many of them have been shown to confer adhesive properties to cells and to play an important role in developmental processes such as cell migration and axon outgrowth. Recent observations implicate Ig superfamily adhesion molecules in the regulation of activity-dependent synaptic plasticity, in regeneration after neural trauma, as well as in the pathogenesis of malformations in the developing nervous systems.
This book summarizes the molecular features and some of the cellular functions of this important class of cell surface molecules. It includes detailed information on the molecular structure of the immunoglobulin fold, the common domain of these proteins, the molecular interactions between various neural Ig superfamily members and their role in signal transduction, as well as the role of Ig superfamily adhesion molecules in axon guidance during both vertebrate and invertebrate neurogenesis. Recent observations on a role for these molecules in activity-dependent synaptic plasticity and in the regeneration of injured axons in the peripheral and central nervous system are described. A discussion on the connection between Ig superfamily adhesion molecules and medical genetics is also provided.
A. Structural Considerations 1. Structural Features of Neural Immunoglobulin Superfamily Adhesion Molecules B. Interactions and Molecular Function 1. Molecular Interactions Involving Immunoglobulin Superfamily Adhesion Proteins 2. NCAM Polysialic Acid 3. Signal Transduction, Neurite Growth and Ig-Superfamily Adhesion Molecules in the Vertebrate System 4. Ig Superfamily Kinases 5. Ig Superfamily Phosphatases C. Role in Neural Development and Plasticity 1. Molecular Mechanisms of Growth Cone Guidance in the Vertebrate Nervous System 2. Genetic Analysis of the Fasciclin II Cell Adhesion Molecule Reveals Multiple Roles During the Generation of Neuronal Specificity 3. Neural Cell Adhesion Molecules in Activity-Dependent Plasticity D. Role in Regeneration and Disease 1. Ig-Superfamily Molecules in Neural Regeneration in the CNS 2. Ig-Superfamily Molecules in Myelination and Regeneration in the Peripheral Nervous System 3. Medical Genetics of Ig Superfamily Molecules