This book provides a highly illustrated and comprehensive account of the diseases of the human bone marrow. It will help experienced clinicians and those in training to answer the practical diagnostic questions that arise during the routine analysis of bone marrow core biopsy specimens. Throughout the text, histologic interpretation is integrated with clinical and laboratory findings. Emphasis is placed on the evaluation of peripheral blood, aspirate smear, clot section and core biopsy, as well as ancillary techniques including flow cytometry and immunohistochemistry in the diagnosis of hematologic disorders of the marrow. The text is illustrated with numerous color figures, charts and tables, and descriptions of real case situations using the most up-to-date classification systems. Illustrated Pathology of Bone Marrow should be read by all pathologists, hematologists and laboratory technicians involved in the analysis of bone marrow specimens.
Attilio Orazi is Professor of Pathology and Director of the Division of Hematopathology at Indiana University School of Medicine. Dennis O'Malley is Assistant Professor in the Division of Hematopathology at Indiana University School of Medicine. Daniel Arber is Professor of Pathology and Director of Clinical Hematology Laboratories at Stanford University Medical Center.
1. Introduction; 2. The normal bone marrow and an approach to bone marrow evaluation of neoplastic and proliferative process; 3. Granulomatous and histiocytic disorders; 4. The aplasias; 5. The hyperplasias; 6. Other non-neoplastic marrow changes; 7. Myelodysplastic syndromes; 8. Acute leukemia; 9. Chronic myeloproliferative disorders and systemic mastocytosis; 10. Myelodysplastic/myeloproliferative disorders; 11. Chronic lymphoproliferative disorders and malignant lymphoma; 12. Immunosecretory disorders/plasma cell disorders and lymphoplasmacytic lymphoma; 13. Metastatic disorders; 14. Post-therapy bone marrow changes.