The major aim of this book is to de-mystify splenic pathology for non-specialist consultants and trainees in histopathology. The interpretation of pathological changes in the human spleen provides a significant challenge to the skills of even the most highly trained histopathologists. This comprehensive account of the most important and frequently encountered pathological conditions affecting the spleen is highly illustrated in colour throughout with numerous detailed macroscopic and microscopic specimens. Emphasis is placed upon the importance of adequate clinical information and technical preparation of splenectomy specimens in obtaining the best possible histopathological assessment of the tissue. A systematic, analytical approach to interpretation of pathological changes is used throughout the book. This should enable readers to feel confident in their assessment of significant processes within the spleen. This volume serves as an illustrated atlas, a bench manual, as a text, and as a source of reference, and will be an indispensable guide.
Preface; 1. Introduction; 2. Normal structure, development and functions of the spleen; 3. Post-traumatic and incidentally removed spleen; 4. The spleen in hereditary blood cell abnormalities and auto-immune disorders; 5. The spleen in immunodeficiency and systemic infections; 6. Lymphomas involving the spleen; 7. The spleen in myeloproliferative disorders; 8. Pathology of the splenic stroma; 9. Metastasise and miscellaneous conditions; 10. Summary: Some key points in splenic differential diagnosis; Index.