Imaging in Drug Discovery and Early Clinical Trials (Progress in Drug Research v. 62 New edition)
By: Markus Rudin (editor)Paperback
2 - 4 weeks availability
This monograph examines the contribution of imaging modalities to the stages of drug discovery and development, from early target validation to their use in clinical development programs. Chapters are devoted to the description of the drug discovery process, to the various imaging modalities preclinically and clinically, to applications of imaging during the optimization of a lead compound, addressing issues such as bioavailability and efficacy, and during drug safety evaluation.
The drug discovery process.- Imaging modalities: principles and information content.- Magnetic resonance and fluorescence based molecular imaging technologies.- Studying molecular and cellular processes in the intact organism.- Disease phenotyping: structural and functional readouts.- Evaluation of drug candidates: Efficacy readouts during lead optimization.- Risk identification and management: MRI as a research tool in toxicology studies of new chemical entities.- Pharmacokinetic studies with PET.- Imaging bio-markers predictive of disease/therapy outcome: ischemic stroke and drug development.- Clinical drug evaluation using imaging readouts: regulatory perspectives.
Number Of Pages:
- ID: 9783764377809
- Saver Delivery: Yes
- 1st Class Delivery: Yes
- Courier Delivery: Yes
- Store Delivery: Yes
Prices are for internet purchases only. Prices and availability in WHSmith Stores may vary significantly
© Copyright 2013 - 2017 WHSmith and its suppliers.
WHSmith High Street Limited Greenbridge Road, Swindon, Wiltshire, United Kingdom, SN3 3LD, VAT GB238 5548 36