The immune system has incredible power to protect us from the ravages of infection. Boosted by vaccines, it can protect us from diseases such as measles. However, the power of the immune system is a double-edged sword: an overactive immune system can wreak havoc, destroying normal tissue and causing diseases such as type I diabetes, rheumatoid arthritis, and multiple sclerosis. The consequences of an impaired immune system, on the other hand, are all too evident in the agonies of AIDS.
Packed with illustrations, stories from Dr. William E. Paul's distinguished career, and fascinating accounts of scientific discovery, Immunity presents the three laws of the human immune system-universality, tolerance, and appropriateness-and explains how the system both protects and harms us. From the tale of how smallpox was overcome and the lessons of the Ebola epidemic to the hope that the immune system can be used to treat or prevent cancer, Dr. Paul argues that we must take advantage of cutting-edge technologies and promising new tools in immunological research.
William E. Paul, MD (1936-2015) was the chief of the Laboratory of Immunology at the National Institute of Allergy and Infectious Diseases of the National Institutes of Health. He received his medical degree from the State University of New York Downstate Medical Center. A past president of the American Association of Immunologists and the American Society for Clinical Investigation, he was also a member of the National Academy of Sciences and its Institute of Medicine and a Fellow of the American Academy of Arts and Sciences.
PrefacePart One1. Defense and Danger2. Tracing an Immune Response3. The Laws of Immunology4. Growing Up and Learning ImmunologyPart Two5. Vaccines and Serum Therapy6. How Is Specificity Achieved?7. Immunology's "Eureka"8. How Does Each Lymphocyte Develop a Distinct Receptor?9. B Cells and T Cells Recognize Different Types of Antigens10. My Foray into the Specificity Problem11. Genes and Immune Responses12. The Laboratory of Immunology and the T-Cell ReceptorPart Three13. What Is Tolerance?14. How Does Tolerance Develop?15. Regulatory T Cells and the Prevention of AutoimmunityPart Four16. Different Structures, Different Functions17. Specific Types of Infections, Specific Types of T-Cell Responses18. Our Discovery of IL-4 and the Cells That Make It19. CD8 T Cells20. Dendritic CellsPart Five21. An "Ancient" Immune Response Controls" Modern" Immunity22. The Microbiome and Innate Immunity23. Evolution of the Immune System and Innate Lymphoid CellsPart Six24. The HIV Epidemic and the Office of AIDS Research25. How the Immune System Causes Rheumatoid Arthritis and Lupus26. Allergy and Asthma27. Interleukin-4 and Allergy28. Can the Immune System Control Cancer?29. New Parts for Old30. JulienConclusionEpilogueAcknowledgmentsNotesIndex