Inducible Gene Expression: Vol 2 - Hormonal Signals (Progress in Gene Expression)
By: P. A. Baeuerle (editor)Hardback
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This is the first of two volumes which aim to cover all established eukaryotic transcription factor systems that are direct targets for the signal transduction pathways. Leading molecular biologists contribute reviews on topics which take a broad view, and which should be of interest to students and advanced researchers in biology and medicine. Chapters attempt to answer such fundamental questions as: what is the signal and how and when is it produced? What is the receptor, and what further signalling molecules are involved? What is the biochemistry and molecular biology of the transcription factor that is the ultimate target of the signalling pathway? What is the physiological role of factor? In this volume, topics covered include: ISGF3 (the interferon response); NF-KB (the pathogenic response); dorsal (the morphogenetic response); NF-AT (the antigen/T-cell response); SRF/TCF (the serum response); DRTF-1/E2F (the cell cycle response); CREB (the cAMP response); and c-Jun (the PMA and UV response).
1 CREM, a Master-Switch in the Nuclear Response to cAMP Signaling.- 2 Signal Uptake by the c-fos Serum Response Element.- 3 DRTF1/E2F: A Molecular Switch in Cell Cycle Control.- 4 Direct Signal Transduction by Tyrosine Phosphorylation of Transcription Factors with SH2 Domains.- 5 The Glucocorticoid Hormone Receptor.- 6 Thyroid Hormone Receptors.- 7 Retinoic Acid Receptors.- 8 Regulation of Nuclear Transport and Activity of the Drosophila Morphogen Dorsal.
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- ID: 9780817637286
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