Industrial Biotransformations (2nd revised and extended ed)

Industrial Biotransformations (2nd revised and extended ed)

By: Christian Wandrey (editor), Karsten Seelbach (editor), Andreas Liese (editor)Hardback

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Description

The completely revised second edition of this user-friendly and application-oriented overview of one-step biotransformations of industrial importance. Based on extensive literature and patent research, this book is unique in arranging each process in a systematic way to allow for easy comparison. All the chapters have been rewritten, with all the processes updated and more than 30 new processes added. Each set of data is accompanied by key literature citations, supported by flow sheets where available, reduced to their significant elements. In addition, an extensive index classified by substrates, products, enzymes, and companies provides direct access to each process, organized according to enzyme class. Biotechnologists, biochemists, microbiologists, process engineers and those working in the chemical and biotechnological industries will find here all the significant parameters characterizing both the biotransformation and the process.

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About Author

Andreas Liese studied chemistry at Friedrich-Wilhelms-University in Bonn, Germany, where he received his PhD in 1998. He carried out his doctoral research at the Research Center Julich, Germany, in close collaboration with DSM Research, Netherlands. From 1998 to 2003, he was assistant professor at the University of Bonn and at the same time head of the Enzyme Group within the Institute of Biotechnology II, Research Center Julich. During a sabbatical in 2000 at Pfizer Global Research & Development, San Diego, USA, he initiated a R&D group on biocatalysis. From 2003 to 2004 he was associate professor at the University of Munster, and has been a full professor of technical biochemistry/biocatalysis at the Hamburg University of Technology as well as director at the Institute of Technical Biocatalysis since 2004. In 2003 he received the award for up-and-coming teachers in higher education in the field of biotechnology, awarded by DECHEMA, Germany. Professor Liese is a member of the "Biotechnology" steering committee of the DECHEMA e.V. and his special research interests are bioprocess engineering, enzyme technology and asymmetric biochemical synthesis. Karsten Seelbach has been working as manager of the Supply Chain Department at Siegwerk Druckfarben AG since the end of 2002. He graduated from Bonn University, Germany, in chemistry / biotechnology in 1997. Before joining McKinsey as a senior consultant in 2001 he worked at Degussa AG in the Process Technology department, focusing on reaction kinetics, process optimization and up-scaling of reactions to production. Karsten Seelbach holds several patents, has published several journal papers, and is co-author of a book on industrial biotransformations. Christian Wandrey carried out his doctoral research at the University of Hanover, receiving his PhD there in 1973, and where he was assistant professor from 1974 to 1977. Thereafter, he worked as associated professor at the University of Clausthal until 1979, when he was made Full Professor of Biotechnology/Chemical Engineering at the University of Bonn and Director at the Institute of Biotechnology at the Research Center Julich, posts he still holds today. Professor Wandrey is a recipient of the Technology-Transfer Prize, the Philip Morris Award, the Enzyme Engineering Award, and the Carl-Friedrich-Gauss-Medaille as well as the Wohler Award. He has more than 300 scientific publications, 100 patents and patent applications, plus over 400 seminars to his name, and is the co-initiator of four start-up companies. His special research interests are enzyme technology, fermentation technology, and downstream processing.

Contents

Preface to the first edition. Preface to the second edition. List of Contributors. 1 History of Industrial Biotransformations - Dreams and Realities (Durda Vasic-Racki). 1.1 From the "Flower of Vinegar" to Recombinant E. Coli - The History of Microbial Biotransformations. 1.2 From Gastric Juice to SweetzymeT - The History of Enzymatic Biotransformations. 1.3 From Wine Bottle to a State-of-the-Art Facility - The History of Biochemical Engineering. 1.4 Advantages of Biotransformations Over Classical Chemistry-Enzymes are proteins, things of beauty and a joy forever. 2 The Enzyme Classification (Christoph Hoh and Murillo Villela FilhoI). 2.1 Enzyme Nomenclature. 2.2 Enzyme Classes. 2.2.1 EC 1 Oxidoreductases. 2.2.2 EC 2 Transferases. 2.2.3 EC 3 Hydrolases. 2.2.4 EC 4 Lyases. 2.2.5 EC 5 Isomerases. 2.2.6 EC 6 Ligases. 3 Retrosynthetic Biocatalysis (Junhua Tao, Alan Pettman, and Andreas Liese). 3.1 Alkanes. 3.2 Alkenes. 3.3 Amines. 3.4 Alcohols. 3.5 Aldehydes. 3.6 Ketones. 3.7 Epoxides. 3.8 Diols. 3.9 Carboxylic Acids. 3.10 Esters. 3.11 Amides. 3.12 Imines. 3.13 Amino Acids. 3.14 Hydroxy Acids. 3.15 a-Hydroxy Ketones. 3.16 b-Hydroxy Aldehydes, Ketones or Carboxylic Acids. 3.17 Cyanohydrins, Hemithioacetals and Hemiaminals. 3.18 Sulfoxides and Sulfones. 3.19 Halides. 3.20 Aromatics (Ring Functionalization). 3.21 Cyclic Compounds. 3.22 Carbohydrates. 3.23 Peroxides. 3.24 Isomers. 3.25 Examples of Retrosynthetic Biotransformations. 3.25.1 Example 1. 3.25.2 Example 2. 4 Optimization of Industrial Enzymes by Molecular Engineering (Thorsten Eggert). 4.1 Introduction. 4.2 Learning from Nature. 4.3 Enzyme Production Using Bacterial Expression Hosts. 4.4 Improvements to Enzymes by Molecular Engineering Techniques. 4.4.1 Rational Enzyme Design. 4.4.2 Directed Evolution. 4.4.3 Random Mutagenesis Methods. 4.5 Identification of Improved Enzyme Variants. 4.6 Conclusions and Future Prospects. 5 Basics of Bioreaction Engineering (Nagaraj N. Rao, Stephan Lutz, Karsten Seelbach, and Andreas Liese). 5.1 Definitions. 5.1.1 Process Definitions. 5.1.2 Definitions of Unit Operations. 5.2 Biocatalyst Kinetics. 5.2.1 Types of Biocatalysts. 5.2.2 Enzyme Structure. 5.2.3 Kinetics. 5.3 Basic Reactor Types and their Modes of Operation. 5.3.1 Mass and Energy Balances. 5.4 Biocatalyst Recycling and Recovery. 5.4.1 Entrapment. 5.4.2 Cross-linking. 5.4.3 Covalent Binding. 5.4.4 Membrane Filtration. 5.5 Reaction Parameters. 5.6 Scale-up of Bioreactors. 5.7 Recent Developments and Trends. 6 Processes (Andreas Liese, Karsten Seelbach, Arne Buchholz, and Jurgen Haberland). Oxireductases EC 1. Transferases EC 2. Hydrolases EC 3. Lyases EC 4. Isomerases EC 5. 7 Quantitative Analysis of Industrial Biotransformation (Adrie J. J. Straathof). Index. Index of enzyme name. Index of strain. Index of company. Index of starting material. Index of product.

Product Details

  • publication date: 03/03/2006
  • ISBN13: 9783527310012
  • Format: Hardback
  • Number Of Pages: 570
  • ID: 9783527310012
  • weight: 1136
  • ISBN10: 3527310010
  • edition: 2nd revised and extended ed

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