The innate immune system comprises the cells and mechanisms that are the first line of defence against infection by other organisms.
This book provides a comprehensive synopsis of eye diseases, their immunological mechanisms and the role of the immune cells and mediators. Beginning with an introduction to the role of the innate immune system, the following chapters discuss the different types of immune cells in the eye and their role in the etiopathogenesis of various diseases including glaucoma and age-related macular degeneration.
Edited by Manfred Zierhut, recognised expert from the University of Tuebingen Germany, this book is presented in an easy to read format, enabling practitioners to understand even the most sophisticated eye disorders from an immunological perspective.
Comprehensive synopsis of the role of the innate immune system in eye diseasesCovers different types of immune cellsEdited by internationally recognised specialist in Germany
Manfred Zierhut MD PhD Professor of Ophthalmology, Centre for Ophthalmology, University of Tuebingen, Germany Friedrich Paulsen MD Professor and Chair, Department of Anatomy II, Friedrich Alexander University of Erlangen-Nuernberg, Germany Jerry Y Niederkorn PhD The George A. and Nancy P. Shutt Professor of Medical Science, Departments of Ophthalmology and Microbiology, UT Southwestern Medical Center Dallas, USA Ulrich Schraermeyer PhD Professor, Centre for Ophthalmology, University Hospital Tubingen, Germany
Chapter 1: Role of the Innate Immune System Chapter 2: Microglial Homeostasis: Lessons from the Mouse Retina Chapter 3: Keratinocyte-Derived Antimicrobial Peptides as Effectors in Innate Skin Defence Chapter 4: The Role of Mucins in the Innate Immune System Chapter 5: Natural Killer Cells Chapter 6: Role of T Cells and Dendritic Cells in Immune-Mediated Diseases Chapter 7: Toll-like Receptors: Structure and Ligand Specificities Chapter 8: Macrophages, Autoimmunity and Control of Tissue Damage Chapter 9: The Innate Immune Response to Cancer Chapter 10: Role of TNF in Host Resistance to Tuberculosis Infection: Membrane TNF is Sufficient to Control Infection Chapter 11: Innate Immunity of the External Eye Chapter 12: Innate Immune System and its Impact on Immune Privilege in the Eye Chapter 13: Myeloid-Derived Cells in the Eye-Distribution, Turnover and Functional Correlates Chapter 14: Linking the Innate and Adaptive Immune Response during the Immunopathogenesis of Dry Eye Disease Chapter 15: Innate Immune Control of Herpes Simplex Virus Replication in the Cornea Chapter 16: Role of the Innate Immune System in Corneal Transplantation Chapter 17: The Innate Immune Response and Autoimmune Uveitis Chapter 18: Innate Immunity of the Eye Glaucoma Chapter 19: The Innate Immunity System and Age-Related Macular Degeneration