Despite recent advances, therapeutic efforts have not been successful establishing a definitive strategy of treatment for brain gliomas, because of the presence of the blood-brain barrier. Innovative Brain Tumor Therapy presents a synopsis of the studies on nanoparticles as ideal devices for brain tumor treatment. Their nanometric size, electrostatic charge, and lipophilic characteristics allow them to penetrate into the brain tissue freely. Promising in-vitro results have been reported, but remain to be validated in humans. This title focuses on the blood-brain barrier pathophysiology in brain tumors, and the possibilities of overcoming this with nanoparticle-based systems. Relevant patents of nanoparticles used as drug delivery carriers are also reported, as well as future scenarios in nanoparticles and stem cells.
Gerardo Caruso is Neurosurgeon at the Department of Neurosciences, School of Medicine, Neurosurgical Clinic, University of Messina, Italy. Lucia Merlo is Neurosurgeon at the Department of Neurosciences, School of Medicine, Neurosurgical Clinic, University of Messina, Italy. Maria Caffo is Assistant Professor in Neurosurgery, Ph.D in Neurooncology at the Department of Neurosciences, School of Medicine, Neurosurgical Clinic, University of Messina, Italy.
* List of figures * List of abbreviations * About the authors * Introduction *1: Brief introduction on brain tumor epidemiology and state of the art in therapeutics* Abstract *2: Blood-brain barrier pathophysiology in brain tumors* Abstract *3: Brain drug-delivery attempts* Abstract *4: Nanoparticles potential: types, mechanisms of action, actual in vitro and animal studies, recent patents* Abstract*4.1 Nanomedicine and nanoparticles: general overview*4.2 Main types of nanoparticles for drug-delivery systems*4.3 Application in brain tumors*4.4 Recent patents in brain tumors*4.5 Nanotechnology *5: Future scenarios: nanoparticles and stem cells* Abstract *6: Conclusions * Index
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- ID: 9781907568596
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