Inositol Phosphates and Derivatives - Synthesis, Biochemistry and Therapeutic Potential (ACS Symposium Series 463)

Inositol Phosphates and Derivatives - Synthesis, Biochemistry and Therapeutic Potential (ACS Symposium Series 463)

By: Allen B. Reitz (editor)Hardback

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Description

This new volume examines the synthesis, biochemistry, and pharmacological evaluation aspects of design compounds with therapeutic effects. Two overview chapters provide comprehensive background information on stereochemistry and nomenclature of inositol phosphates, basic biochemistry, synthetic challenges, and related pharmacology. Subsequent chapters describe novel methods of preparation, including the use of unusual starting materials and mediation by microorganisms, therapeutic potential and bioactivity, and structure-activity relationships.

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Contents

Biochemistry, Stereochemistry, and Nomenclature of the Inositol Phosphates ; Phosphoinositides and Their Stimulated Breakdown ; Enantiospecific Synthesis and Ca^2]+-Release Activities of Some Inositol Polyphosphates and Their Derivatives ; Synthesis of Inositol Polyphosphates and Their Derivatives ; Synthesis of myo-Inositol Polyphosphates ; Preparation of Optically Active myo-Inositol Derivatives as Intermediates for the Synthesis of Inositol Phosphates ; Pharmacolotical Effects of D-myo-Inositol-1,2,6-Trisphosphate ; Synthesis of New myo-Inositol Derivatives Containing Phosphate, Sulfate, and Sulfonamido Groups ; Chemical Modifications of Inositol Trisphosphates: Tritiated, Fluorinated, and Phosphate-Tethered Analogues ; Novel Routes to Inositol Phosphates Using Pseudomonas putida Oxidation of Arenes ; Enantiospecific Synthesis of Inositol Polysphophates, Phosphatidylinositides, and Analogues from (-)-Quinic Acid ; Synthesis and Complexation Properties of Inositol-Phosphates ; Phosphorothioate Analogues of Phosphatidylinositol and Inositol 1,2-Cyclic Phosphate: Application to the Mechanism of Phospholipase C ; Phosphorothioate Analogues of D-myo-Inositol 1,4,5-Trisphosphate: Chemistry and Biology ; Synthesis and Biological Evaluation of Inositol Derivatives as Inhibitors of Phospholipase C ; Synthesis and Biological Evaluation of Inositol Phospholipid Analogues

Product Details

  • publication date: 01/01/1991
  • ISBN13: 9780841220867
  • Format: Hardback
  • Number Of Pages: 235
  • ID: 9780841220867
  • weight: 466
  • ISBN10: 0841220867

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