Diabetes is now one of the major causes of morbidity worldwide. In many cases, the onset of diabetes is progressive, developing via a condition of insulin resistance. This book considers the development of this condition, its consequences and clinical and therapeutic aspects. The book reviews the normal biology of insulin action on glucose, lipids and proteins. It considers the pathological basis for insulin resistance in animal models and humans, and discusses the influence of heredity, dietary factors and exercise. Clinical consequences including dyslipidaemia, hypertension and polycystic ovary syndrome, and therapeutic strategies for treatment are also examined. * Provides an expert review of the phenomenon of insulin resistance * Brings together a host of recent research for the first time * Written by leading experts in biological and clinical research
Preface.List of Contributors1. The Insulin Receptor and Downstream Signalling (Ken Siddle).2. Insulin-Mediated Regulation of Glucose Metabolism (Daniel Konrad, Assaf Rudich and Amira Klip).3. Insulin Action on Lipid Metabolism (Keith N. Frayn and Fredrik Karpe).4. The Effect of Insulin on Protein Metabolism (Laura J. S. Greenlund and K. Sreekumaran Nair).5. Genetically Modified Mouse Models of Insulin Resistance (Gema Medina, Christopher Lelliott and Antonio J. Vidal-Puig).6. Insulin Resistance in Glucose Disposal and Production in Man with Specific Reference to Metabolic Syndrome and Type 2 Diabetes (Henning Beck-Nielsen, Frank Alford and Ole Hother-Nielsen).7. Central Regulation of Peripheral Glucose Metabolism (Stanley M. Hileman and Christian Bjorbak).8. Relationship Between Fat Distribution and Insulin Resistance (Philip G. McTernan, Aresh Anwar and Sudhesh Kumar).9. PPARy and Glucose Homeostasis (Robert K. Semple and Stephen O'Rahilly).10. Adipokines and Insulin Resistance (Daniel K. Clarke and Vidya Mohamed-Ali).11. Dietary Factors and Insulin Resistance (Jeremy Krebs and Susan Jebb).12. Physical Activity and Insulin Resistance (Nicholas J. Wareham, Soren Brage, Paul W. Franks and Rebecca Abbott).13. Genetics of the Metabolic Syndrome (George Argyropoulos, Steven Smith and Claude Bouchard).14. Insulin Resistance and Dyslipidaemia (Benoit Lamarche and Jean-Francois Mauger).15. Insulin Resistance, Hypertension and Endothelial Dysfunction (Stephen J. Cleland and John M. C. Connell).16. Insulin Resistance and Polycystic Ovary Syndrome (Neus Potau).17. Syndromes of Severe Insulin Resistance (SSIRs) (David Savage and Stephen O'Rahilly).18. Therapeutic Strategies for Insulin Resistance (Harpal S. Randeva, Margaret Clarke and Sudhesh Kumar).19. Drug Therapy for Insulin Resistance - a Look at the Future (Bei B. Zhang and David E. Moller).Index.