Integrated Nano-Biomechanics provides an integrated look into the rapidly evolving field of nanobiomechanics. The book demystifies the processes in living organisms at the micro- and nano-scale through mechanics, using theoretical, computational and experimental means. The book develops the concept of integrating different technologies along the hierarchical structure of biological systems and clarifies biomechanical interactions among different levels for the analysis of multi-scale pathophysiological phenomena. With a focus on nano-scale processes and biomedical applications, it is shown how knowledge obtained can be utilized in a range of areas, including diagnosis and treatment of various human diseases and alternative energy production.
This book is based on collaboration of researchers from a unique combination of fields, including biomechanics, computational mechanics, GPU application, electron microscopy, biology of motile micro-organisms, entomological mechanics and clinical medicine. The book will be of great interest to scientists and researchers involved in disciplines, such as micro- and nano-engineering, bionanotechnology, biomedical engineering, micro- and nano-scale fluid-mechanics (such as in MEMS devices), nanomedicine and microbiology, as well as industries such as optical devices, computer simulation, plant based energy sources and clinical diagnosis of the gastric diseases.
Takami Yamaguchi is an Emeritus Professor at the Graduate School of Biomedical Engineering, Department of Biomedical Engineering, Tohoku University, Japan. Takuji Ishikawa is Professor at the Graduate School of Engineering, Department of Finemechanics, Tohoku University, Japan. Yohsuke Imai is an Associate Professor at the School of Engineering, Tohoku University, Japan.
Section 1: Introduction to nano-biomechanics T. Yamaguchi Section 2: Biomechanics of microcirculation Chapter 2.1 Behavior of capsules in flow S. Nix Chapter 2.2 Behavior of red blood cells T. Omori Chapter 2.3 Adhesion of cells Y. Imai Chapter 2.4 Formation and destruction of the primary thrombus H. Kamada Section 3: Biomechanics of digestive systems Chapter 3.1 Dynamics of swallowing Y. Imai Chapter 3.2 Mixing in stomach Y. Imai Chapter 3.3 Transport phenomena of gut flora T. Ishikawa Section 4: Biomechanics for pathology and treatment Chapter 4.1 Development of cerebral aneurysms Y. Shimogonya Chapter 4.2 Electroporation for cancer treatment N. Matsuki Chapter 4.3 Microbubbles for blood transfusion N. Matsuki Chapter 4.4 Percutaneous absorption of medicine K. Kikuchi Section 5: Ciliary motion Chapter 5.1 Ciliary structure H. Ueno Chapter 5.2 Motor proteins of cilia H. Ueno Chapter 5.3 Computational modeling of ciliary motion T. Omori Section 6: Swimming microorganisms Chapter 6.1 Swimming of a solitary cell Y. Shimogonya Chapter 6.2 Suspension of swimming cells T. Ishikawa Chapter 6.3 Bioconvection generated by microalgae A. Kage Section 7: Microfluidic devices based on biomechanics Chapter 7.1 Measurement techniques of cellular flow R. Lima Chapter 7.2 Controlling cell-free layer M. Saadatmand Chapter 7.3 Separation of motile bacteria T. Ishikawa Section 8: Biomimetics Chapter 8.1 - Design of fish fin K. Kikuchi Chapter 8.2 - Bloodsucking of mosquito K. Kikuchi Chapter 8.3 - Virtual chameleon F.Mizuno