This monograph summarizes the latest knowledge of the clinical application of interferons in malignant disease with emphasis on hairy cell leukaemia, lymphoma, multiple myeloma, chronic myloid leukaemia, lung cancer, melanoma and renal carcinoma. There are chapters on the use of animal models for studying the anti-tumor and anti-metastatic activities of interferons and the relationship between endogenous and exogenous interferon production and oncogene expression. The clinical use of interferons in combination with cytotoxic drugs and radiation is reviewed together with guidelines for future directions of clinical and experimental research.
Contents: The Role of Interferon in the Treatment of B-Cell Malignancies.- Interferon in the Treatment of Hairy Cell Leukemia and Chronic Myelogenous Leukemia.- Natural Alpha Interferon as Part of a Combined Treatment for Small-Cell Lung Cancer.- Alpha Interferon Alone or in Combination with Chemotherapy in the Treatment of Malignant Melanoma, Renal Cell Carcinoma and Other Solid Tumours.- Interferons Combined with Other Anti-Cancer Agents - Studies in Experimental Systems.- Animal Models for Studying Antitumour and Antimetastatic Activities of Interferons.- Reduction of Nuclear Oncogene Expression by Endogenous and Exogenous Interferons.- Summary: Current Status and Future Directions.
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Softcover reprint of the original 1st ed. 1987