In the clinical neurosciences, decision-making becomes ever more complicated because of rapidly emerging new diagnostic tests and treatments and increasing demands from patients to participate in their management. This concise but wide-ranging handbook reviews the epidemiology of neurological disease and the treatment and prognosis of all major diseases of the nervous system. Part one offers essential guidance for clinicians to quantitative methods in research, including genetic epidemiology, decision analysis, meta-analysis, outcomes research and survival analysis, and thus provides a good understanding of the evidence underlying clinical management. The second part is devoted to individual neurological diseases, covering etiology, diagnosis, prognosis, interventions, and implications for clinical practice. With contributions from leading international authorities, this book is an invaluable guide to clinical decision-making for neurologists and others involved in the management of neurological disease.
Part I. Quantitative Methods in Clinical Neurology: 1. Clinical research design: analytical studies Richard Mayeux; 2. Genetic epidemiology in neurologic disease Ruth Ottman; 3. Gene-environment interaction in neurologic disorders C. M. van Duijn; 4. Analysis, reanalysis and meta-analysis in neurology Walter A. Rocca; 5. Epidemiology for clinical neurology W. A. van Gool; 6. Decision analysis in clinical neurology Diederik W. J. Dippel; 7. Outcomes research in clinical neurology Mitchell S. V. Elkind and Ralph L. Sacco; 8. Survival analysis in neurological disease John F. Kurtzke and Mitchell T. Wallin; 9. The clinical trial in efficacy research in neurological diseases J. van Gijn and M. Vermeulen; Part II. Neurological Diseases: 10. Cerebrovascular ischemic disease Philip A. Wolf; 11. Vascular dementia Richard K. Chan and Vladimir Hachinski; 12. Alzheimer's disease Ingmar Skoog and Kaj Blennow; 13. Parkinson's disease Maarten C. de Rijk and Monique M. B. Breteler; 14. Multiple sclerosis A. Alperovitch; 15. Myasthenia gravis Therese A. Treves; 16. Guillain-Barre syndrome F. G. A. van der Meche and R. van Koningsveld; 17. Encephalitis and meningitis Ettore Beghi; 18. HIV infection Ned C. Sacktor, Gerald J. Dal Pan and Justin C. McArthur; 19. Prion diseases Cornelia M. van Duijn; 20. Neoplastic disease John F. Annegers; 21. Cerebral palsy Karin B. Nelson; 22. Migraine Ann I. Scher, Richard B. Lipton and Walter F. Stewart; Index.