Isoquinoline Alkaloids

Isoquinoline Alkaloids

By: K. W. Bentley (author)Hardback

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Description

The Isoquinoline Alkaloids presents an in-depth review of 22-sub groups of isoquinoline alkaloids all related to their common origin from the amino-acids phenylalanine and tyrosine. The coverage is not intended to be comprehensive and encyclopaedic, but all of the salient features of the elucidation of structures, structural variation, stereochemistry, chemical reactions, syntheses, biogenetic origins and relationships, and pharmacology are covered, and an extensive bibliography of original papers is provided to assist further detailed study. The opening chapter comprises a review of the formation of alkaloids from amino-acids and the general methods of structural degradation used in the definitive elucidations of structures. Two final chapters cover napthylisoquinolines, which are biogenetically distinct from those discussed in earlier chapters, and miscellaneous natural products that are rationally included with other groups. This book should be of interest to graduates and researchers in the field of organic chemistry, natural product chemistry and biochemistry.

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Contents

1. ISOQUINOLINE ALKALOIDS - ORIGINS AND DEGREDATION 2. ss-PHENYLETHYLAMINES AND SIMPLE ISOQUINOLINES 2.1 Structures 2.2 Syntheses 2.3 Chemical Properties 2.4 Polymeric Isoquinolines 2.5 N-Benzylisoquinolines 2.6 1-Phenylisoquinolines 2.7 4-Phenylisoquinolines 2.8 Biogenesis 2.9 Pharmacology References 3. 1-BENZOISOQUINOLINES 3.1 Structures 3.2 Syntheses 3.3 Chemical Properties 3.4 Biogenesis 3.5 Pharmacology References 4. BISBENZYLISOQUINOLINES 4.1 Singly-Linked Dimers 4.2 Doubly-Linked Dimers 4.3 Triply-Linked Dimers 4.4 Oxidised Alkaloids 4.5 Benzoisoquinoline-Benzodiazepine Dimer 4.6 Syntheses 4.7 Biogenesis 4.8 Pharmacology References 5. CULARINE AND RELATED ALKALOIDS 5.1 Structures 5.2 Oxidised Alkaloids 5.3 A Rearranged Alkaloid 5.4 Cularine-Morphinan Dimers 5.5 Syntheses 5.6 Biogenesis 5.7 Pharmacology References 6. PAVINES AND ISOPAVINES 6.1 Pavine Alkaloids 6.2 Isopavine Alkaloids 6.3 Syntheses 6.4 Dimeric Alkaloids 6.5 Biogenesis 6.6 Pharmacology References 7. DIBENZOPYRROCOLINES 7.1 Structures 7.2 Biogenesis References 8. APORPHINOID ALKALOIDS 8.1 Aporphines 8.2 Syntheses of Aporphines 8.3 Secoaporphines 8.4 Oxoaporphines 8.5 Dioxoaporphines 8.6 Aristolactams 8.7 Aristolochic Acids 8.8 Dimeric Aporphines 8.9 Proaporphines 8.10 Aporphinoid-Benzylisoquinoline Dimers 8.11 Oxo-isoaporphines 8.12 Azafluoranthenes and Related Tropolones 8.13 Ring-C Cleaved Alkaloids 8.14 Biogenesis of Aporphinoid Alkaloids 8.15 Pharmacology References 9. EMETINE AND RELATED ALKALOIDS 9.1 Benzylisoquinoline Dimers 9.2 Benzylisoquinoline-Tryptamine Dimers 9.3 Monobasic Alkaloids 9.4 Azaberberines 9.5 Syntheses 9.6 Biogenesis 9.7 Pharmacology References 10. BERBERINES AND TETRAHYDROBERBERINES 10.1 Determination of Structure 10.2 General Reactions of Berberine 10.3 Reactions of Tetrahydroberberines 10.4 Syntheses 10.5 Bimolecular Berberines 10.6 Biogenesis 10.7 Pharmacology References 11. SECOBERBERINES 11.1 Structures 11.2 Syntheses 11.3 Biogenesis 11.4 Pharmacology References 12. PHTHALIDE-ISOQUINOLINES 12.1 Structures 12.2 Modified Alkaloids 12.3 Syntheses 12.4 Biogenesis 12.5 Pharmacology References 13. PROTOPINES 13.1 Structures 13.2 Syntheses 13.3 Biogenesis 13.4 Pharmacology References 14. SPIRO-BENZYLISOQUINOLINES 14.1 Structures 14.2 Syntheses 14.3 Biogenesis 14.4 Pharmacology References 15. INDANOBENZAEPINES 15.1 2,3-Indano-4,5-benzaepines 15.2 6,7-Indano-3,4-benzaepines 15.3 Pharmacology References 16. RHOEADINES 16.1 Structures 16.2 Syntheses 16.3 Biogenesis 16.4 Pharmacology References 17. BENZOPHENANTHRIDINES 17.1 Structures 17.2 Syntheses 17.3 Biogenesis 17.4 Pharmacology References 18. OTHER MODIFIED BERBERINES 18.1 Isoindolobenzazepines 18.2 Isoindoloiosquinolines 18.3 Isoindolobenzazepines 18.4 Spirobenzazepines 18.5 Isoquinolinoisoquinolines 18.6 Biogenesis References 19. PHENETHYLISOQUINOLINES 19.1 Phenethylisoquinolines 19.2 Bisphenethylisoquinolines 19.3 Homoaporphines 19.4 Homoproaporphines 19.5 Homoaporphinan Alkaloids 19.6 Syntheses 19.7 Biogenesis 19.8 Azaproaporphines References 20. COLCHICINE AND RELATED ALKALOIDS 20.1 Colchicine 20.2 Analogues of Colchicine 20.3 Reactions of Colchicine 20.4 Ring-contracted Alkaloids 20.5 Syntheses 20.6 Biogenesis 20.7 Pharmacology References 21. ERYTHRINA ALKALOIDS 21.1 Structures 21.2 Alkaloids of Cocculus Species 21.3 Azaerythrinanes 21.4 Syntheses 21.5 Biogenesis 21.6 Pharmacology References 22. HOMOERYTHRINA ALKALOIDS 22.1 Structures 22.2 Syntheses 22.3 Biogenesis 22.4 Pharmacology References 23. CEPHALOTAXINE AND RELATED ALKALOIDS 23.1 Structures 23.2 Syntheses 23.3 Biogenesis 23.4 Pharmacology References 24. NAPTHYLIOSQUINOLINES 24.1 Structures 24.2 Syntheses 24.3 Biogenesis 24.4 Pharmacology References 25. OTHER ISOQUINOLINE ALKALOIDS 25.1 Jamtine N-oxide 25.2 Leptocarpine 25.3 Aaptamine 25.4 Necatorone 25.5 Mimosamycin 25.6 Mimocin 25.7 Renierone 25.8 Saframycins A, B and C 25.9 Naphthyridinomycin 25.10 Quinocarcin (quinocarmycin) 25.11 Ecteinascidins References 26. ADDENDA Index

Product Details

  • publication date: 02/06/1998
  • ISBN13: 9789057022296
  • Format: Hardback
  • Number Of Pages: 512
  • ID: 9789057022296
  • weight: 1052
  • ISBN10: 905702229X

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