Isotope Dilution Mass Spectrometry (IDMS) has become an essential tool in research laboratories and is increasingly used in routine analysis labs (including environmental, food safety and clinical applications). This is the first textbook to present a comprehensive and instructive view of the theory and applications of this growing technique.
The main objective of this book is to cover the theory and applications of Isotope Dilution in Analytical Chemistry. The scope is comprehensive to include elemental analysis, speciation analysis, organic analysis and biochemical and clinical analysis together with applications in metabolism studies and traceability of goods. Until now there have been no books published with the same general scope (only book chapters on particular applications). This is a textbook focused at post-graduate level covering the basic knowledge required for doctoral studies in this field. Isotope Dilution Mass Spectrometry will also outline practical applications of interest for routine testing laboratories where isotope dilution procedures are implemented or can be implemented in the future. This unique book covers all the theoretical and practical aspects of Isotope Dilution Mass Spectrometry (IDMS). Due to the increasing application of IDMS in many research laboratories and the increasing implementation of IDMS methodologies in routine testing laboratories, scientists in industry and working in or affiliated to this area will this an invaluable source of information. Concerning the theoretical aspects, the authors present a uniform theoretical background which grows from previous developments in Organic, Speciation and Elemental analysis both in their own laboratory and in other laboratories around the world. This general approach will be simpler and will also include new emerging fields such as quantitative proteomics and metabolism studies.
Dr Pablo Rodriguez Gonzalez has carried out his PhD and his postdoc in the field of Isotope dilution analysis for speciation and organic analysis. He is co-author of about 30 publications in international journals on IDMS using different inorganic and organic mass spectrometric techniques. He has written in collaboration with Prof. Garcia Alonso a tutorial review in 2005 which has been already cited 82 times since its publication in 2005.
1 Introduction to Isotope Dilution Mass Spectrometry (IDMS);2 IDMS Procedures and Calculation Methods; 3 Online Isotope Dilution Mass Spectrometry; 4 The Use of Multiple Enriched Isotopes for IDMS; 5 The Isotope Composition of Natural-Abundance Elements and Molecules; 6 Selection of Isotopically Enriched Elements and Isotopically Labelled Molecules; 7 The Measurement of the Isotope Composition of the Elements; 8 The Measurement of the Isotope Composition of Molecules by Mass Spectrometry; 9 Traceability in Isotope Dilution Mass Spectrometry; 10 Uncertainty Evaluation in IDMS; Appendix Definition and Explanation of Symbols Used; Subject Index