Joint Models of Longitudinal and Time-to-Event Data: With Applications in R (Chapman & Hall/CRC Biostatistics Series 6)

Joint Models of Longitudinal and Time-to-Event Data: With Applications in R (Chapman & Hall/CRC Biostatistics Series 6)

By: Dimitris Rizopoulos (author)Hardback

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In longitudinal studies it is often of interest to investigate how a marker that is repeatedly measured in time is associated with a time to an event of interest, e.g., prostate cancer studies where longitudinal PSA level measurements are collected in conjunction with the time-to-recurrence. Joint Models for Longitudinal and Time-to-Event Data: With Applications in R provides a full treatment of random effects joint models for longitudinal and time-to-event outcomes that can be utilized to analyze such data. The content is primarily explanatory, focusing on applications of joint modeling, but sufficient mathematical details are provided to facilitate understanding of the key features of these models. All illustrations put forward can be implemented in the R programming language via the freely available package JM written by the author. All the R code used in the book is available at:

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About Author

Dimitris Rizopoulos is an Assistant Professor at the Department of Biostatistics of the Erasmus University Medical Center in the Netherlands. Dr. Rizopoulos received his M.Sc. in Statistics in 2003 from the Athens University of Economics and Business, and a Ph.D. in Biostatistics in 2008 from the Katholieke Universiteit Leuven. Dr. Rizopoulos wrote his dissertation, as well as a number of methodological articles on various aspects of joint models for longitudinal and time-to-event data. He currently serves as an Associate Editor for Biometrics and Biostatistics, and has been a guest editor for a special issue in joint modeling techniques in Statistical Methods in Medical Research.


Introduction Inferential Objectives in Longitudinal Studies Case Studies Organization of the Book Analysis of Longitudinal Data Features of Repeated Measures Data Linear Mixed Effects Models Dropout in Longitudinal Studies Analysis of Time-to-Event Data Features of Event Time Data Relative Risk Models Time-Dependent Covariates Joint Models for Longitudinal and Time-to-Event Data The Standard Joint Model Connection with the Dropout Framework Extensions of the Standard Joint Model Parameterizations Multiple Failure Times Latent Class Joint Models Diagnostics Residuals for the Longitudinal Submodel Residuals for the Survival Submodel Random Effects Distribution Prediction and Accuracy in Joint Models Dynamic Predictions for the Survival and Longitudinal Outcomes Effect of the Parameterization on Predictions Prospective Accuracy Measures for Longitudinal Markers

Product Details

  • publication date: 09/07/2012
  • ISBN13: 9781439872864
  • Format: Hardback
  • Number Of Pages: 275
  • ID: 9781439872864
  • weight: 536
  • ISBN10: 1439872864

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