'This book is the first volume in the Key Clinical Trials series. This series will cover the main areas of urology. Forthcoming volumes include. Incontinence, Prostate Cancer. Erectile Dysfunction and Bladder Cancer.' Over the last two decades the medical management of the symptoms of BPH has evolved considerably from being the exclusive domain of the urological surgeon and the use of drugs by both specialists and primary care physicians has increased dramatically. This book, the first in 'The Key Clinical Trials Series' contains analyses of some of the key clinical trials that have influenced our approach to the treatment of BPH. Each trial is judged on it strengths and weaknesses and a diagrammatic summary of the trial design and key results are included. This is an ideal overview of the major developments in the field of BPH for both trainee and practicing urologists. It is a uniquely concise and insightful resource that will provide the reader with a new level of understanding of the subject and avenues for further research and study.
From the contents: Phenoxybenzamine - treatment of benign prostatic obstruction.- Terazosin - management of the symptoms associated with BPH.- Terazosin - long-term treatment of the symptomatic BPH.- The utility of Finasteride - long-term management of symptomatic BPH.- Finasteride efficacy over 5 years.- Finasteride impact on acute urinary retention and surgical intervention over 4 years.- Leuprolide - treatment of BPH.- Alfuzosin - long-term medical management of BPH.- Alfuzosin - a long-term follow-up of patients in a community based setting.- Doxazosin in normotensive and controlled hypertensive patients.- Doxazosin, in normotensive patients and in patients with concomitant hypertension.- Doxazosin in hypertensive and normotensive patients.- Alfuzosin.- Doxazosin.- Comparison of Terazosin, Finasteride and both in combination, for the treatment of BPH.- Phytotherapy compared to Finasteride .- Transurethral surgery versus watchful waiting for the treatment of moderate symptoms of BPH.- The AUA Symptom Index.- Placebo therapy .- Analysis of the 'placebo effect'.