Providing a description of the fundamentals and applications in the field of laser-tissue interaction, this book covers basic concepts such as the optical and thermal properties of tissue, the various types of tissue ablation and optical breakdown and its related effects. Special attention is given to mathematical tools (Monte Carlo simulations, the Kubelka-Munk theory and others) and approved techniques (photodynamic therapy, laser-induced interstitial thermotherapy and others). The part on applications reviews clinically relevant methods in medicine using the modern references. The last chapter covers contemporary thermotherapy standards of laser safety, with a careful selection of guidelines published by the Laser Institute of America. The book is intended as a guide for graduate students, scientists, and medical practitioners.