The book will be arranged into two sections; Basic Science and Clinical Science, to enable the scientist and the more clinically focused reader to readily access the required information. Topics covered will include lipoprotein structure, function and metabolism, with particular emphasis on diabetes-related changes, lipoprotein related research techniques, clinically available research tools, recent major diabetes and lipid related clinical trials, effects of lifestyle and glycemic control on lipoproteins, and the use of the major lipid modifying medications.
1. Overview Basic Science 2. Lipoprotein structure and function 3. Lipoprotein metabolism including changes in diabetes Lipoprotein classes 4. triglyceride rich lipoproteins (including chylomicrons, vldl and their remnants) 5. LDL 6. Lipoprotein (a) 7. HDL Lipoprotein related genes, enzymes and receptors 8. lipoprotein related genes 9. Lipoprotein related enzymes -- 1 (Endothelial based lipases) 10. Lipoprotein related enzymes -- 2 (LCAT and CETP, PON and PAFAH)) 11. lipoprotein receptors 12. Lipoprotein vascular wall interactions 13. PPAR system in diabetes lipoprotein modifications 14. lipoprotein glycation 15. lipoprotein oxidation lipoproteins and immune complexes lipoprotein related research tools 17. lipoprotein kinetics 18. lipoprotein subclassing 19. lipoproteins and cellular interactions 20. Animal models of diabetic dyslipoproteinemia Clinical Science 21. the clinical measurement of lipoproteins lipoproteins and vascular damage in diabetes 22. lipoproteins and endothelial dysfunction 23. lipoproteins and cardiovascular disease 24. Lipoproteins and diabetic nephropathy 25. lipoproteins and diabetic retinopathy 26. recommended treatment targets and aids to their achievement lipoprotein related trials in diabetes 27. lipoprotein related trials in diabetes overview (including macro- and microvascular trials) specific major trials in diabetes or with major diabetes sub-studies 28. Heart proectection study 29. cards (statin related) 30. VA-HIT study (Gemfibrozil related) 31. FIELD study (Fenofibrate related) treatments of lipoprotein disorders in diabetes 32. effects of lifestyle and glycemic control on lipoproteins in diabetes 33. effects of drugs on lipoproteins in diabetes 34. HMG CoA Reductase Inhibitors 35. Fibric acid derivatives 36. cholesterol absorption inhbitiors including resins and ezetemibe 37. other drugs / treatments in development including ldl apharesis, cetp inhibitors and hdl mimetics 38. combination drug therapies in diabetes 39. Future directions