This is the second edition of a very well received book devoted specifically to the treatment of liver tumors by radioembolization with 90Y microspheres. The success of the first edition was based on the provision of all the fundamental information required for successful use of this therapeutic modality in clinical practice. The new edition has been fully updated to cover the most recent advances and includes additional chapters on regulations and emerging trends. Detailed information is provided on the full range of relevant topics, including hepatic vascular anatomy (including variants), dosimetry, assessment of tumor response, and the results achieved using radioembolization alone and in combination with other treatments in patients with primary or metastatic disease. Complications and side-effects are also fully discussed. This book will prove immensely valuable for both beginners and practitioners.
Introduction.- 90Y Microspheres: Concepts and Principles.- Regulations and requirements of hospitals performing radioembolization.- Radiological evaluation of patients with liver tumors.- Vascular anatomy and its implication in radioembolization.- Radioembolization: Identifying and managing anatomic variants.- Dosimetry and Dose Calculation.- Nuclear Medicine Procedures for Treatment Evaluation.- Histologic evaluation after Liver Radioembolization.- Radiological Detection and Assessment of Tumor Response.- Evaluation of the response by multimodality imaging.- Results in hepatocellular carcinoma.- Radioembolization combined with other therapeutic local and systemic treatments in hepatocellular carcinoma.- Results in Liver Metastatic Colorectal Cancer.- Radioembolization combined with other therapeutic local and systemic treatments in colorectal liver metastases.- Use of Yttrium-90 Radioembolization in the Treatment of Unresectable Hepatic Metastases from Neuroendocrine Tumors.- Ytrium 90 Radioembolization for other liver metastases.- Complications and side effects.- Radioembolization Induced Liver Disease.- Future Directions in Radioembolization.