Making Drugs from Fragments: Starting Simple and Keeping It Simple is both a practical tool for chemists and an accessible guide for their managers on the best ways to implement and optimize fragment-based drug design in their work.
As a method that offers great benefits in terms of economic viability, rapidity of results, and good success rates, fragment-based drug design has quickly been embraced by the drug discovery community. Combining strong coverage of foundational knowledge with expert tips and techniques, this book is designed to provoke new ideas and discussion amongst seasoned professionals, while also helping those in non-scientific roles evaluate the opportunities and benefits of implementing fragment-based design at their organizations.
Beginning with an introduction to the rules and metrics of fragment-based lead discovery and how to assess their usefulness, the book then reviews methods for prioritizing targets, designing fragment libraries, and the potential for combining fragment-based methods with high-throughput screening for the benefit of both.
In addition, users will find sections on methods for taking simple fragments and optimizing them to simple drug-like candidates and a practical overview of why fragments might not develop and optimize as expected. Finally, the book concludes by asking if processes and accumulated data can be simplified and standardized to increase the efficiency of fragment-based drug discovery.