Management of Chemical and Biological Samples for Screening Applications

Management of Chemical and Biological Samples for Screening Applications

By: Terry Wood (editor), Mark Wigglesworth (editor)Hardback

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Description

Filling an obvious gap in the scientific literature, this practice-oriented reference is the first to tie together the working knowledge of large screening centers in the pharmaceutical and biotechnological field. It spans the entire fi eld of this emerging discipline, from compound acquisition to collection optimization for specific purposes, to technology and quality control. In so doing, it applies two decades of expertise gathered by several large pharmaceutical companies to current and future challenges in high-throughput screening. With its treatment of libraries of small molecules as well as biobanks containing biomolecules, microorganisms and tissue samples, this reference is universally applicable for any molecular scientist involved in a large screening program.

About Author

Mark Wigglesworth manages the UK Lead Optimization area of Sample Management Technologies for GlaxoSmith-Kline. Over the past 10 years Mark has managed large and small compound stores, assay ready plate production and compound set provision, as well as interacting with many areas of drug discovery. Additionally, he has led several drug discovery programs and overseen multiple screening platforms providing structure activity relationship data within GlaxoSmithKline?s screening organizations. Now a freelance business consultant, Terry Wood retired in 2011 as the manager of the Liquid Store Centre of Emphasis at Pfizer?s world-wide R&D department, based in Sandwich (UK). He has been involved in the high-throughput screening process for the whole of his 25 year career with Pfizer. This has given him a first hand and broad knowledge about the challenges and caveats of assay design, development and prosecution. His prime responsibility focused on the management of Pfizer?s extensive compound file, using a range of automated systems for sample preparation, storage and delivery.

Contents

Preface XIX List of Contributors XXIII 1 Introduction to Sample Management 1 William P. Janzen and Andy Zaayenga References 6 2 Generating a High-Quality Compound Collection 9 Philip B. Cox and Anil Vasudevan 2.1 Defining Current Screening Collections 9 2.2 Design Criteria for Enriching a Compound Collection with Drug-Like Compounds 10 2.3 Concluding Remarks 20 References 20 3 Assessing Compound Quality 23 Ioana Popa-Burke, Stephen Besley, and Zoe Blaxill 3.1 Introduction 23 3.2 Process Quality and Analytical Quality in Compound Management 24 3.3 Identity 28 3.4 Purity/Stability 32 3.5 Concentration/Solubility 39 3.6 Conclusions 41 Acknowledgments 41 References 42 Further Reading 44 4 Delivering and Maintaining Quality within Compound Management 45 Isabel Charles 4.1 Introduction 45 4.2 What is Quality from a Compound Management Perspective? 46 4.3 Storage and Delivery of Samples in Solution 47 4.4 Intercepting Low Purity 49 4.5 Storage and Delivery of Solids 51 4.6 Automation Quality Control and Reliability 52 4.7 High-Quality Data Management 54 4.8 Conclusion 55 Acknowledgments 56 References 56 5 Obtaining and Maintaining High-Quality Tissue Samples: Scientific and Technical Considerations to Promote Evidence-Based Biobanking Practice (EBBP) 59 Lisa B. Miranda 5.1 Introduction 59 5.2 The Path toward Integration of Evidence-based Biobanking Practice 62 5.3 Integrating Evidence-based Biobanking Practice into Sample Protocols 66 5.4 Final Thoughts and Recommendations 74 References 79 6 Thinking Lean in Compound Management Laboratories 83 Michael Allen 6.1 The Emergence of Lean Thinking 83 6.2 The Application of Lean Thinking 83 6.3 Lean Thinking in Drug Discovery 86 6.4 A Lean Laboratory Toolbox 87 6.5 Streamlining Compound Processing An Example 101 6.6 Summary 103 References 105 7 Application of Supply Management Principles in Sample Management 107 Paul A. Gosnell 7.1 Introduction 107 7.2 Common Pitfalls of Sample Management 107 7.2.1 One Size Does Not Fit All 108 7.3 Sample Management and Supply Chain Concepts 108 7.4 Implementing the Sample Management Strategy 111 7.5 Sample Management Organization 111 7.6 Sample Management Informatics 113 7.7 Avoid Monolithic Silos of Excellence 114 7.8 Position and Synchronize Inventory 115 7.9 Expand the Sample Management Boundary 117 7.10 Measuring and Assessing Effectiveness and Quality 118 7.11 Conclusions 119 References 120 8 Solid Sample Weighing and Distribution 121 Michael Gray and Snehal Bhatt 8.1 The Practicalities and Technology of Weighing Solid Compounds 121 8.2 Logistical Challenges of Transportation of Small Molecules 127 References 142 9 Managing a Global Biological Resource of Cells and Cellular Derivatives 143 Frank P. Simione and Raymond H. Cypess 9.1 Introduction 143 9.2 Diversity of Collections 144 9.3 Sourcing and Acquisition 148 9.4 Authentication and Characterization 149 9.5 Cryopreservation, Storage, and Production 153 9.6 Data Management 154 9.7 Quality and Standards 155 9.8 Order Fulfillment and Distribution 157 9.9 Offsite Biorepository Management 158 9.10 Regulatory and Legal Compliance 159 9.11 Ownership and Intellectual Property Management 160 9.12 Collaborations 161 9.13 Conclusion 162 References 163 10 Development of Automation in Sample Management 165 Gregory J. Wendel 10.1 Introduction 165 10.2 Historical Background 165 10.3 Automation of Sample Management Today 167 10.4 System Building Blocks 169 10.5 Storage Systems 171 10.6 Liquid Handler 175 10.7 Accessories 180 10.8 Plate Handling, Integration 184 10.9 Case Study: Evolution of a Compound Management Group 186 10.10 Results 196 References 197 11 Applications of Acoustic Technology 199 Eric Tang, Colin Bath, and Sue Holland-Crimmin 11.1 Introduction 199 11.2 Compound-Handling Challenges in Drug Discovery 201 11.3 Acoustic Drop Ejection Performance, Quality Assurance, and Platform Validation 203 11.4 Acoustic-Assisted Compound Solubilization and Mixing 206 11.5 Acoustic Applications in Drug Discovery 209 11.6 Emerging Applications 216 References 218 12 Enhancing Biorepository Sample Integrity with Automated Storage and Retrieval 221 Johann van Niekerk 12.1 The Emerging Growth of Biobanking 221 12.2 Automated Storage and Retrieval in a Biorepository 225 12.3 Configuration of an Automated Biorepository 236 12.4 Conclusions 241 References 241 13 Information Technology Systems for Sample Management 243 Brian Brooks 13.1 Sample Registration 243 13.2 Intellectual Property and Laboratory Notebooks 253 13.3 Some Observations on Information Technology 254 13.4 Biological Data Management 255 Dedication and Acknowledgments 263 14 Key Features of a Compound Management System 265 Clive Battle 14.1 Why Do We Need Compound Management Information Technology Systems? 265 14.2 Compound Management Software 266 14.3 Benefits of Commercially Available Compound Management Systems 272 References 273 15 What Does an HTS File of the Future Look Like? 275 Francois Bertelli 15.1 Introduction 275 15.2 History of Compounds Collection for HTS 276 15.3 Impact of High-Throughput Chemistry on Corporate Files 277 15.4 Chemical Library Management 278 15.5 The Concept of Drug-Likeness and the Lipinski Rules 279 15.6 Quality versus Quantity 283 15.7 The Emergence of the Subsets: Fragment, G-Protein-Coupled Receptor (GPCR), Ion Channel, Kinase, Protein Protein Interaction, Chemogenomics, Library Of Pharmacologically Active Compounds (LOPAC), Central Nervous System (CNS), and Diversity 285 15.8 Re-designing the Corporate File for the Future 291 15.9 Future Routes for Hit Identification 299 References 301 16 New Enabling Technology 305 Neil Hardy, Ji Yi Khoo, Shoufeng Yang, Holger Eickhoff, Joe Olechno, and Richard Ellson 16.1 Introduction 305 16.2 A Drop-On-Demand Printer for Dry Powder Dispensing 307 16.3 Piezo Dispense Pens: Integrated Storage and Dispensing Devices and their Potential in Secondary Screening and Diagnostic Manufacturing 312 16.4 Future Directions in Acoustic Droplet Ejection Technology 323 16.5 Closing Remarks 347 References 347 17 The Impact of Future Technologies within Biobanking 351 Manuel M. Morente, Laura Cereceda, and Mar' a J. Artiga 17.1 Introduction 351 17.2 The Role of Biobanks in Biomedical Research 351 17.3 The Increasing Complexity of Biobanking 354 17.4 Future Technologies and Biobanking: How Could New Technologies Affect the Daily Activities of Biobanks? 356 17.5 The Future of Biobanking Does Not Depend on Technological Developments Alone 363 17.6 Conclusions 364 Acknowledgments 364 References 364 18 Outsourcing Sample Management 367 Sylviane Boucharens and Amelia Wall Warner 18.1 Outsourcing in the Pharmaceutical Industry 367 18.2 Outsourcing Biological Specimen Collections 374 18.3 Conclusions 378 Acknowledgments 378 References 378 19 Sample Management Yesterday and Tomorrow 381 Terry Wood and Mark Wigglesworth 19.1 The Role of Sample Management 381 19.2 Automation of Compound Management 382 19.3 Compound Integrity 384 19.4 Reduction of Redundancy 386 19.5 The Future of Sample Management? 387 19.6 Concluding Remarks 390 References 391 Index 393

Product Details

  • ISBN13: 9783527328222
  • Format: Hardback
  • Number Of Pages: 432
  • ID: 9783527328222
  • weight: 938
  • ISBN10: 352732822X

Delivery Information

  • Saver Delivery: Yes
  • 1st Class Delivery: Yes
  • Courier Delivery: Yes
  • Store Delivery: Yes

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