This book explores a fascinating aspect of cell biology that is emerging as pivotal for a variety of signaling processes in cells throughout the body and is also a focus of abnormalities in various pathological conditions. Microdomains, also called lipid rafts are now recognized as playing fundamental roles in regulating a range of cellular processes from proliferation and differentation to signal transduction responses to a variety of stimull. In this book, experts in the field of lipid rafts and signal transduction provide detailed reviews of the current state of understanding of these membrane microdomains and their physiological and pathophysiological roles. Better understanding of the effects of dietary lipids on raft function may lead to novel ways to prevent and treat various diseases that involve abnormalities in lipid rafts.
From Intramolecular Asymmetries to Raft Assemblies: A Short Guide for the Puzzled in Lipidomics; Ephraim Yavin and Annette Brand; Regulatory Aspects of Membrane Microdomain (Raft) Dynamics in Live Cells: A Biophysical Approach; Janos Matko and Janos Szollosi; Lipid Raft Membrane Skeletons; Elizabeth J. Luna, Thomas Nebl, Norio. Takizawa, and Jessica L. Crowley; Role of Cholesterol in Membrane Microdomain Signaling; Christopher J. Fielding; Raft Lipid Metabolism in Relation to Alkyl-Lysophospholipid-Induced Apoptosis; Arnold H. van der Luit, Marcel Verheij, and Wim J. van Blitterswijk; Role of Lipid Rafts in Signal Transduction and Synaptic Plasticity of Neural Cells; Markus Delling and Melitta Schachner; Role of Rafts in Virus Fusion and Budding; Wu Ou and Jonathan Silver; Alterations in Raft Lipid Metabolism in Aging and Neurodegenerative Disorders; Mark P. Mattson, Roy G. Cutler, and Norman J. Haughey; Caveolin and Cancer: A Complex Relationship; Mordechai Liscovitch, Elke Burgermeister, Neeru Jain, Dana Ravid, Maria Shatz, and Lilach Tencer; Dietary Modulation of Lipid Rafts: Implications for Disease Prevention and Treatment; Mark P. Mattson