Merkel cell carcinoma is an uncommon but not rare aggressive cutaneous malignancy. It has many similarities to melanoma, particularly in the need for aggressive multidisciplinary treatment, but far less is known about this disease by most practicing physicians. This book summarizes all of the existing knowledge about Merkel cell carcinoma and provides a much-needed perspective on future opportunities for diagnostic and therapeutic advances. It offers practical "how to" advice on diagnosis, treatment and follow-up, and also insight into how to establish a multidisciplinary Merkel cell carcinoma clinic. In addition, it will serve as a unique resource for trainees (medical students, residents and fellows) as well as for Merkel cell carcinoma patients and their advocates and caregivers. There is currently no such textbook, even an outdated one, covering this topic.
Introduction: Multidisciplinary Management of Merkel Cell Carcinoma (V K Sondak et al.); Etiology and Epidemiology of Merkel Cell Carcinoma (Agelli); Basic Biology of Merkel Cell Carcinoma (Becker); Molecular Profiling and Genomic Analysis in Merkel Cell Carcinoma (Weeraratna); Pathology of Merkel Cell Carcinoma (J L Messina); Recognition and Diagnosis of Merkel Cell Carcinoma (Glass & Lien); Current Staging Systems for Merkel Cell Carcinoma (Ngheim); New Prognostic Factors in Merkel Cell Carcinoma (J S Zager & J L Messina); Role of Imaging Studies in Merkel Cell Carcinoma (Berman); Surgical Management of Primary and Regional Merkel Cell Carcinoma (J S Zager & Cruse); Special Considerations in the Management of Head and Neck Merkel Cell Carcinoma (Cruse et al.); Role of Mohs Micrographic Surgery in Merkel Cell Carcinoma (Cherpelis); Radiation in the Management of Primary and Regional Merkel Cell Carcinoma (Trotti); Adjuvant Systemic Therapy of Merkel Cell Carcinoma (R C DeConti & Daud); Management of Metastatic Merkel Cell Carcinoma (R C DeConti & Daud); Potential for Targeted Therapy in Merkel Cell Carcinoma (Samlowski); Potential for Immunotherapy in Merkel Cell Carcinoma (Weber); Establishing a Multidisciplinary Merkel Cell Carcinoma Clinic (Bichakjian & Wong); Appendices: Standardized Follow-Up Regimen for Merkel Cell Carcinoma Patients (Puleo & J S Zager); Information About Merkel Cell Carcinoma for Patients, Family Members and Caregivers (Lien et al.); Internet Resources Relating to Merkel Cell Carcinoma for Providers, Patients, Family Members and Caregivers (J L Messina et al.).