Written and edited by recognized experts in the field, the new "Artech House Methods in Bioengineering" book series offers detailed guidance on authoritative methods for addressing specific bioengineering challenges. Offering a highly practical presentation of each topic, each book provides research engineers, scientists, and students with step-by-step procedures, clear examples, and effective ways to overcome problems that may be encountered. Providing alternatives to animal testing is one of the hottest topics in biomedical research, and this groundbreaking volume addresses this critical issues head on. This unique book presents techniques and methods at the forefront of scientific research that have the potential to replace certain whole animal tests. Moreover, this book provides a platform where other widely accepted techniques and scientific advancements can be collated into a concise set of methods that can be implemented within both academic and industrial communities.
Tim Maguire works at a startup company, where he is pursuing the creation of in vitro drug screening systems, integrating optimized human hepatocyte cultures with microfluidic systems. He holds a B.S. in chemical engineering and a Ph.D. in biomedical engineering, both from Rutgers University. Eric Novik works at a startup company and is involved in all aspects of development and commercialization of patented microfluidic, cell-based platforms for use in drug discovery and development, consumer and industrial product testing, and related fields. He holds a B.S. and a Ph.D. in biomedical engineering from Rutgers University.
Current Methods for Prediction of Human Hepatic Clearance Using In Vitro Intrinsic Clearance. Aggregating Brain Cell Cultures for Neurotoxicity Tests. Approaches Towards a Multi-Scale Model of Systemic Inflammation in Humans. Epigenetically Stabilized Primary Hepatocyte Cultures: A Potential Sensitive Screening Tool for Non-Genotoxic Carcinogenicity. Application of the Benchmark Apporach in the Correlation of In Vitro and In Vivo Data in Developmental Toxicity. 3D Culture of Primary Chonrocytes, Cartilage, and Bone/Cartilage Explants in Simulated Microgravity. Alternatives for Absorption Testing. A 3D Model of the Human Epithelial Airway Barrier.