MicroRNAs have recently emerged as key regulators of gene expression during development and are frequently misexpressed in human disease states, in particular cancer. These 22-nucleotide-long transcripts act to promote or repress cell proliferation, migration and apoptosis during development, all of which are processes that go awry in cancer. Thus, microRNAs have the ability to behave like oncogenes or tumor suppressors. In addition, their small size and molecular properties make them amenable as targets and therapeutics in cancer treatment. This book goes into detail on how microRNAs represent a paradigm shift in thinking about gene regulation during development and disease, and provide the oncologist with a potentially powerful new battery of agents to diagnose and treat cancer.
Introduction to Small RNAs (A Abbott); The Emerging Non-coding RNA World (J Mattick); MicroRNAs and siRNAs (J Kim); MicroRNAs in C. elegans Development (H Grosshans); MicroRNAs in Vertebrate Development (M McManus); MicroRNAs in Hematopoetic Development (S Monticelli); piRNAs (H Lin); Introduction to MicroRNAs in Cancer: Historical Perspective (S Hammond); MicroRNA Control of Cell Proliferation and Differentiation (A Esquela-Kerscher); Profiling MicroRNAs in Cancer (T Schmittgen); MicroRNAs as Potential Diagnostics and Therapeutics (J Weidhaas); SNPs in MicroRNA and Their Targets (I Rigoutsos); Other Non-coding RNAs in Cancer (G Calin).