At long last, the complete spectrum of the aldol reaction is presented here in this two-volume handbook. Top authors guarantee contributions of the highest quality, beginning with fundamentals and then moving on to enolates and catalytic aldol reactions, including the Mukaiyama Reaction. Further sections are devoted to enzymatic aldol reactions in synthesis as well as such related reactions as the Henry, Ene and Aldol-Tishchenko reactions. The wealth of information contained here allows a comprehensive overview of this important topic in organic chemistry, removing the need for the hitherto time-consuming research among the widely dispersed literature. With a foreword by Professor D. A. Evans.
Born in 1950, Rainer Mahrwald studied chemistry at MLU Halle and subsequently joined the "Manfred von Ardenne" Research Institute in Dresden, where he led the synthetics group. He gained his doctorate under G. Wagner in Leipzig in 1979, and went on to the Institute of Organic Chemistry at the Academy of Science in Berlin, where he remained until 1990. Following a stay at the Philipps-University in Marburg, Dr. Mahrwald qualified as a lecturer at the Humboldt University Berlin, where he is now a private lecturer.
Fundamentals and Transition State Models.The Development of Titanium Enolate Based Aldol Reactions.Boron and Silicon Enolates in Crossed Aldol Reaction.Silver, Gold and Palladium Lewis-Acids.Boron and Silicon Lewis Acids for Mukaiyama Aldol Reactions.Copper Lewis Acids.Tin-promoted Aldol Reactions and Their Applications to Total Syntheses of Natural Products.Zirconium Alkoxides as Lewis Acids.Direct Catalytic Asymmetric Aldol Reaction Using Chiral Metal Complexes.Catalytic Enantioselective Aldol Additions with Chiral Lewis Bases.Amine-Catalyzed Aldol Reactions.Enzyme Catalyzed Aldol Additions.Antibody-Catalyzed Aldol Reactions.The Aldol-Tishchenko Reaction.The Aldol Reaction in Natural Product Synthesis: The Epothilone Story.