This book presents all important aspects of modern alkaloid chemistry, making it the only work of its kind to offer up-to-date and comprehensive coverage. While the first part concentrates on the structure and biology of bioactive alkaloids, the second one analyzes new trends in alkaloid isolation and structure elucidation, as well as in alkaloid synthesis and biosynthesis. A must for biochemists, organic, natural products, and medicinal chemists, as well as pharmacologists, pharmaceutists, and those working in the pharmaceutical industry.
Ernesto Fattorusso was assistant professor at the University of Naples (1963-75); in 1975 he became full Professor of Organic Chemistry at the Faculty of Science. In 1980 he moved to the Faculty of Pharmacy, where he was elected Dean twice. In 2002 he won the A. Quilico Award (Societa Chimica Italiana) and in 2004 the P. Scheuer Award (Akademie of Erfurt). He has published more than 300 research papers. Orazio Taglialatela Scafati got the Ph.D. in "Bioactive Natural Products" in 1997, under the supervision of Prof. Fattorusso. Currently, he is Associate Professor in Organic Chemistry, Faculty of Pharmacy, University of Naples "Federico II". His research interests deal with isolation, structure elucidation and semisynthetic transformations of bioactive secondary metabolites from marine invertebrates and terrestrial plants. He is the author of 45 research papers and the editor of the book "Flavour and Fragrance Chemistry".
Preface BIOACTIVE ALKALOIDS: STRUCTURE AND BIOLOGY Ecological Roles of Alkaloids Antitumor Alkaloids in Clinical Use or in Clinical Trials Alkaloids and the Bitter Taste Capsaicin and Capsaicinoids Glycosidase-Inhibiting Alkaloids: Isolation, Structure, and Application Neurotoxic Alkaloids from Cyanobacteria Lamellarin Alkaloids: Structure and Pharmacological Properties Manzamine Alkaloids Antiangiogenic Alkaloids from Marine Organisms A Typical Class of Marine Alkaloids: Bromopyrroles Guanidine Alkaloids from Marine Invertebrates NEW TRENDS IN ALKALOID ISOLATION AND STRUCTURE ELUCIDATION Analysis of Tropane Alkaloids in Biological Matrices LC-MS of Alkaloids: Qualitative Profiling, Quantitative Analysis, and Structural Identification Applications of 15NNMR Spectroscopy in Alkaloid Chemistry NEW TRENDS IN ALKALOID SYNTHESIS Synthesis of Alkaloids by Transition Metal Mediated Oxidative Cyclizations Camptothecin and Analogues: Structure and Synthetic Efforts Combinatorial Synthesis of Alkaloid-like Compounds In Search of Chemical Probes of Protein-Protein Interactions Daphniphyllum Alkaloids: Structures, Biogenesis, and Activities Structure and Biosynthesis of Halogenated Alkaloids Engineering Biosynthetic Pathways to Generate Indolocarbazole Alkaloids in Microorganisms