This book focuses on the functional significance of targeting apoptosis for the treatment of prostate cancer. New concepts on the challenges relating to the development of resistance by androgen-independent tumors are introduced, in terms of the contribution of anoikis and cross-talk of androgens with key growth factor signaling pathways. This volume also provides insightful discussion on the exploitation of the apoptotic and angiogenic synergism towards complete eradication of prostate tumors. Last but not least, it includes reflections on the drug development challenge based on the analysis of data from existing clinical trials.
Introduction - Apoptosis: General Aspects of a Highly Specific Cell Death Mission; Apoptosis Signaling Pathways: The Road to Eliminating Cancer Cells; Novel Therapeutic Targeting of Apoptosis Pathways for Androgen-Independent Prostate Cancer; Apoptosis Players Provide Valuable Novel Biomarkers of Prostate Cancer Progression; Future Exploitation of Apoptotic/Angiogenic Synergism.