Combining theoretical knowledge of synthetic transformations, practical considerations, structural elucidation by interpretation of spectroscopic data as well as rationalization of structure-property relations, this textbook presents a series of 16 independent exercises, including detailed descriptions of experimental procedures, questions, and answers. The experimental descriptions are very helpful for guiding less experienced students towards a better understanding of practical aspects in synthetic organic chemistry, while the broad scope of the questions and answers is excellent for learning purposes. The exercises are based on published research articles, adapted for didactic purposes, and will thus inspire students by way of having to solve real-life problems in chemistry. A must-have for MSc and PhD students as well as postdocs in organic chemistry and related disciplines, and lecturers and organizers of lab courses in organic chemistry.
Nicolas Bogliotti is Assistant Professor at Ecole normale superieure Paris-Saclay, France. After his undergraduate studies at Universite Nice Sophia-Antipolis, France, he obtained his MSc and PhD Degrees at Universite Pierre et Marie Curie in Paris, France. He was a postdoc at ETH Zurich, Switzerland and Institut Curie, France, before his current position. His research interests focus on the synthesis of photosensitive molecules allowing visualization of recognition events, induction of a biological response and modulation of chemical reactivity. Roba Moumne is Assistant Professor at Universite Pierre et Marie Curie, France. She studied chemistry and completed her MSc and PhD at the same university. Before her current position, she was also a postdoctoral fellow at Max-Planck-Institut in Mulheim and der Ruhr, Germany, at University of Zurich, Switzerland and at Universite Paris Descartes, France. Her research interests include bioorganic chemistry and peptide synthesis.
Foreword 1) Atovaquone: An Antipneumocystic Agent 2) SEN794: A SMO Receptor Antagonist 3) Synthesis of a H1-H3 Antagonist 4) Synthesis of Eletriptan 5) Total Synthesis and Structure Revision of Streptophenazine A 6) Synthesis of Leiodermatolide: A Biologically Active Macrolide 7) Total Synthesis of Stemoamide 8) Total Synthesis and Structure Revision of Caraphenol B 9) Synthetic Routes Towards Muricatacin and Analogues 10) Asymmetric Synthesis of (-)-Martinellic Acid