Muscle 2-Volume Set: Fundamental Biology and Mechanisms of Disease

Muscle 2-Volume Set: Fundamental Biology and Mechanisms of Disease

By: Eric Olson (editor), Joseph Hill (editor)Mixed Media

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A valuable study of the science behind the medicine, Muscle: Fundamental Biology and Mechanisms of Disease brings together key leaders in muscle biology. These experts provide state-of-the-art insights into the three forms of muscle--cardiac, skeletal, and smooth--from molecular anatomy, basic physiology, disease mechanisms, and targets of therapy. Commonalities and contrasts among these three tissue types are highlighted. This book focuses primarily on the biology of the myocyte. Individuals active in muscle investigation--as well as those new to the field--will find this work useful, as will students of muscle biology. In the case of hte former, many wish to grasp issues at the margins of their own expertise (e.g. clinical matters at one end; molecular matters at the other), adn this book is designed to assist them. Students, postdoctoral fellows, course directors and other faculty will find this book of interest. Beyond this, many clinicians in training (e.g. cardiology fellows) will benefit.

About Author

Dr. Hill is a cardiologist-scientist whose research strives to decipher mechanisms of structural, functional, and electrical remodeling of the heart. He earned M.D. and Ph.D. degrees from Duke University, conducted postdoctoral scientific training with Jean-Pierre Changeux at the Institut Pasteur in Paris, and pursued clinical training in Internal Medicine and Cardiology at Brigham and Women's Hospital, Harvard Medical School. Dr. Hill served on faculty at the University of Iowa for 5 years before moving in 2002 to UT Southwestern as Chief of Cardiology and Director of the Harry S. Moss Heart Center. Dr. Hill's honors include election to the Association of University Cardiologists and the Association of American Physicians. Dr. Hill maintains an active clinical practice focusing on general cardiology, hypertension, and heart failure. Dr. Olson has dedicated his career to deciphering mechanisms that control muscle gene regulation and development. He received B.A. and Ph.D. degrees from Wake Forest University. After postdoctoral training with Luis Glaser at Washington University School of Medicine, he joined the Department of Biochemistry and Molecular Biology at the M. D. Anderson Cancer Center in 1984 and became Professor and Chairman in 1991. In 1995, he founded the Department of Molecular Biology at UT Southwestern. Dr. Olson has received numerous prestigious awards and honors. He is a member of the American Academy of Arts and Sciences, and its Institute of Medicine.


Part 1: Introduction 1. An Introduction to Muscle 2. A History of Muscle Part II: Cardiac Muscle Section A: Basic Physiology 3. Cardiac Myocyte Specification and Differentiation 4. Transcriptional Control of Cardiogenesis 5. Cardiomyocyte Ultrastructure 6. Overview of CArdiac Muscle Physiology 7. Ionic Fluxes and Genesis of the Cardiac Action Potential 8. G-Protein-Coupled Receptors in the Heart 9. Receptor Tyrosine Kinases in Cardiac Muscle 10. Communication in the Heart: Cardiokines as Mediators of a Molecular Social Network 11. Calcium Fluxes and Homeostasis 12. Excitation-Contraction Coupling in the Heart 13. Role of Sarcomeres in Cellular Tension, Shortening, and Signaling in Cardiac Muscle 14. Cardiovascular Mechanotransduction 15. Cardiomyocyte Metabolism: All Is in Flux 16. Transcriptional Control of Striated Muscle Mitochondrial Biogenesis and Function 17. Mitochondrial Morphology and Function 18. Genetics and Genomics in Cardiovascular Gene Discovery 19. Cardiovascular Proteomics: Assessment of Protein Post-Translational Modifications Section B: Adaptations and Response 20. Adaption and Responses: Myocardial Innervations adn Neural Control 21. Regulation of Cardiac Systolic Function and Contractility 22. Intracellular Signaling Pathways in Cardiac Remodeling 23. Oxidative Stress and Cardiac Muscle 24. Physiologic and Molecular Responses of the Heart to Chronic Exercise 25. Epigenetics in Cardiovascular Biology 26. Cardiac MicroRNAs 27. Protein Quality Control in Cardiomyocytes 28. Cardioprotection 29. Cardiac Fibrosis: Cellular and Molecular Determinants 30. Autophagy in Cardiac Physiology and Disease 31. Programmed Cardiomyocyte Death in Heart Disease 32. Wnt and Notch: Potent Regulators of Cardiomyocyte Specification, Proliferation, and Differentiation Section C: Myocardial Disease 33. Congenital Cardiomyopathies 34. Genetics of Congenital Heart Disease 35. Mechanisms of Stress-Induced Cardiac Hypertrophy 36. Ischemic Heart Disease 37. The Pathophysiology of Heart Failure 38. The Right Ventricle: Reemergence of the Forgotten Ventricle 39. Mammalian Myocardial Regeneration 40. The Structural Basis of Arrhythmia 41. Molecular and Cellular Mechanisms of Cardiac Arrhythmias 42. Genetic Mechanisms of Arrhythmia 43. Infiltrative adn Protein Misfolding Myocardial Diseases 44. Cardiac Aging: From Humans to Molecules 45. Adrenergic Receptor Polymorphisms in Heart Failure 46. Cardiac Gene Therapy 47. Protein Kinases in the Heart: Lessons Learned from Targeted Cancer Therapeutics 48. Cell Therapy for Cardiac Disease 49. Chemical Genetics of Cardiac Regeneration 50. Device Therapy for Systolic Ventricular Failure 51. Novel Therapeutic Targets and Strategies against Myocardial Diseases Part III: Skeletal Muscle Section A: Basic Physiology 52. Skeletal Muscle Development 53. Skeletal Muscle: Architecture of Membrane Systems 54. The Vertebrate Neuromuscular Junction 55. Neuromuscular Interactions that Control Muscle Function and Adaptation 56. Control of Resting CA2+ Concentration in Skeletal Muscle 57. Skeletal Muscle Excitation-Contraction Coupling 58. The Contractile Machinery of Skeletal Muscle 59. Skeletal Muscle Metabolism 60. Skeletal Muscle Fiber Types Section B: Adaptations and Response 61. Regulation of Skeletal Muscle Development and Function by microRNAs 62. Musculoskeletal Tissue Injury and Repair: Role of Stem Cells, Their Differentiation, and Paracrine Effects 63. Immunological Responses to Muscle Injury 64. Skeletal Muscle Adaptation to Exercise 65. Skeletal Muscle Regeneration 66. Skeletal Muscle Dystrophin-Glycoprotein Complex and Muscular Dystrophy Section C: Skeletal Muscle Disease 67. Statin-Induced Muscle Toxicity: Clinical and Genetic Determinants of Risk 68. Myotonic Dystrophy 69. Facioscapulohumeral Muscular Dystrophy: Unraveling the Mysteries of a Complex Epigenetic Disease 70. ECM-Related Myopathies and Muscular Dystrophies 71. Molecular Pathogenesis of Skeletal Muscle Abnormalities in Marfan Syndrome 72. Diseases of the Nucleoskeleton 73. Channelopathies of Skeletal Muscle Excitability 74. Thick and Thin Filament Proteins: Acquired adn Hereditary Sarcomeric Protein Diseases 75. Metabolic and Mitochondrial Myopathies Section D: Therapeutics 76. Gene Therapy of Skeletal Muscle Disorders Using Viral Vectors 77. Cell-Based Therapies in Skeletal Muscle Disease 78. Immunological Components of Genetically Inherited Muscular Dystrophies: Duchenne Muscular Dystrophy and Limb-Girdle Muscular Dystrophy 79. Myostatin: Regulation, Function, and Therapeutic Applications 80. Insulin-Like Growth Factor I Regulation and Its Action in Skeletal Muscle Growth and Repair 81. Novel Targets and Approaches to Treating Skeletal Muscle Disease Part IV: Smooth Muscle Section A: Basic Physiology 82. Development of the Smooth Muscle Cell Lineage 83. Smooth Muscle Myocyte Ultrastructure 84. Potassium, Sodium, and Chloride Channels in Smooth Muscle Cells 85. G-Protein-Coupled Receptors in Smooth Muscle 86. Calcium Homeostasis and Signaling in Smooth Muscle 87. Regulation of Smooth Muscle Contraction Section B: Heterogeneities 88. Heterogeneity of Smooth Muscle 89. Microcirculation 90. Uterine Smooth Muscle Section C: Adaptations and Response 91. Oxidative Stres, Endothelial Dysfunction, and Its Impact on Smooth Muscle Signaling 92. Hemodynamic Control of Vascular Smooth Muscle Function 93. Myogenic Tone and Mechanotransduction 94. Cell-Cell Communication Through Gap Junctions 95. Vascular Smooth Muscle Cell Phenotypic Adaptation 96. Molecular Pathways of Smooth Muscle Disease Section D: Smooth Muscle Disease 97. Genetic Variants in Smooth Muscle Contraction and Adhesion Genes Cause Thoracic Aortic Aneurysms and Dissections and Other Vascular Diseases 98. Vascular Smooth Muscle Cell Remodeling in Atherosclerosis and Restenosis 99. Arterial Hypertention 100. Diabetic Vascular Disease 101. Vascular Mechanisms of Hypertension in the Pathophysiology of Preeclampsia 102. Erectile Dysfunction 103. Smooth Muscle in the Normal and Diseased Pulmonary Circulation 104. Airway Smooth Muscle and Asthma 105. Aging 106. Vascular Calcification 107. Smooth Muscle Progenitor Cells: A Novel Target for the Treatment of Vascular Disease? 108. Smooth Muscle: Novel Targets and Therapeutic Approaches

Product Details

  • ISBN13: 9780123815101
  • Format: Mixed Media
  • Number Of Pages: 1528
  • ID: 9780123815101
  • weight: 4870
  • ISBN10: 012381510X

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