Neuroinflammation: Mechanisms and Management (Contemporary Neuroscience)
By: Gar Wood (author)Hardback
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An unprecedented review of our current knowledge of the neuroinflammatory mediators and cells involved in neurodegenerative diseases. Beginning with a detailed review of our current concepts of which biochemical mediators are involved in neuronal loss and the mechanisms of cell death, the distinguished contributors critically examine those areas of current research involved in the design of specific pharmacological agents to inhibit at defined points in the neuroinflammatory cascade. They also address the molecular, cellular, and disease model actions of first-generation agents, as well as the potential clinical relevance to AIDS-related dementia, Alzheimer's disease, amyotropic lateral sclerosis (ALS), Down's syndrome, Huntington's disease, multiple sclerosis, Parkinson's disease, and stroke.
Part I. Microglia. Roles of CNS Macrophages in Neurodegeneration P. L. Wood. Inflammatory Markers in Chronic Neurodegenerative Disorders with Emphasis on Alzheimer's Disease D. G. Walker. Inflammatory Markers in Stroke H. Kato. Microgliosis and Impaired Cognition D. Giulian and J. Li. Part II. Acute Phase Proteins. Strategies for Inhibition of Complement Activation in the Treatment of Neurodegenerative Diseases K. Spiegel M. R. Emmerling and S. R. Barnum. Inflammatory Mechanisms of Alzheimer's Disease: Basic Research Clinical Studies and Future Directions J. Rogers and W. S. T. Griffin. Part III. Cytokines. Role of IL- 1 in Neurodegeneration: Preclinical Findings with IL-1ra and ICE Inhibitors D. Martin G. Miller T. Neuberger J. Relton and N. Fischer. Cytokines in Severe Head Injury L. Ott C. McClain S. Scheff J. Hatton and B. Young. Neuroimmune Mechanisms in the Treatment of Multiple Sclerosis R. Lechtenberg. Part IV. Free Radicals. Reactive Oxygen Involvement in Neurodegenerative Pathways: Causes Consequences and Potential Management with Nitrone-Based Free Radical Traps K. Hensley Q. Pye T. Tabatabaie C. A. Stewart and R. A. Floyd. Utility of the 21-Aminosteroids in Spinal Cord Injury E. D. Hall. Part V. Miscellaneous Mediators. Role of Cell Adhesion Molecules in Neurological Disorders D. P. Andrew. The Role of Glial Nitric Oxide in Neurotoxicity and Central Nervous System Diseases K. M. K. Boje. Inducible Cyclooxygenase (COX-2): A Target for Novel Anti-Inflammatory Drugs I. W. Rodger and C.-C. Chan. Index.
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- ID: 9780896034167
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