An overview of findings on the biology of neutrophils. These cells have become a focus of attention because of their fascinating biochemistry and molecular biology and their ability to affect the functions of other cells. The book describes, in detail, the molecular events leading to neutrophil activation, migration, microbial killing, production of oxidative radicals and cytokines, and eventually to the death of these cells. It also provides an overview of the neutrophil's role in viral diseases, including AIDS. Finally, the book describes how to improve the function of neutrophils and use these cells in the treatment of diseases.
Molecular basis of neutrophil activation, D. English; the respiratory burst of neutrophils - oxidative pathways for the initiation of tissue damage at sites of inflammation, J.W. Heinecke; mechanism of leukocyte accumulation in postischemic tissues - role of oxygen free radicals, J.L. Zweier; regulation of neutrophil functions by fatty acids, A. Ferrante et al; production of cytokines by polymorphonuclear neutrophils, M.A. Cassatella; neutrophils and apoptosis, N.F. Fanning et al; neutrophil migration and methods for its in vitro study, A. Rot; diagnostic evaluation of neutrophil function, G. Virella; neutrophils in viral infections, R.L. Roberts; use of colony-stimulating factors for treatment of neutropenia and infectious diseases, D.C. Dale and S. Nelson; neutrophil transfusion therapy, R.G. Strauss.