The processes and techniques of manufacturing have changed substantially over the decades and that evolution continues today. In order to examine the potential impacts of these changes, the Department of Commerce asked the NRC to design a workshop to focus on issues central to the changing nature of manufacturing. The workshop brought together a number of experts to present papers about and to discuss the current state of manufacturing in the United States and the challenges it faces. This report presents the results of that workshop. Key challenges that emerged from the workshop and that are discussed include understanding manufacturing trends; manufacturing globalization; information technology opportunities; maintaining innovation; strengthening small and medium-sized enterprises; workforce education; and rising infrastructure costs.