Non-covalent Interactions In Proteins

Non-covalent Interactions In Proteins

By: Andrey Karshikoff (author)Hardback

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Description

Although textbooks on the physics of condensed matter consider non-covalent interactions in detail, their application for analysis of protein properties is often poorly presented or omitted. On the other hand, books on biochemistry, molecular modeling or molecular simulation introduce these interactions in the context of the corresponding topic, which sometimes results in superficial explanations of their nature. This book succeeds in uniting comprehensive considerations of non-covalent interactions with the specificity of their application in protein sciences.The ideal aid for students of physics or chemistry, with interests in biology and biophysics, the book can also be useful for students of biology, biochemistry, or biomedicine who want to extend their knowledge of how protein properties are described at the molecular level.

Contents

Overview of Protein Structural Elements and Basic Definitions; Non-covalent Interactions and Structure-Function Relationships in Proteins; Observation of van der Waals Interactions; Nature of van der Waals Interactions; Potential Functions for Application in Proteins; Approximation for Polyatomic Systems; Nature of Hydrogen Bonds; Geometry and Strength of the Hydrogen Bond; Hydrogen Bonds in Proteins; Hydrogen Bonds and Protein Stability; Nature of Hydrophobic Interactions, Pseudo Forces; Water; Hydrophobic Effect; Hydrophobic Interactions in Proteins; Debye-Huckel Theory; Ion-Solvent Interactions; Calculation of Electrostatic Interactions in Proteins; Why Does One Need to Know Ionization Equilibria?; Factors Determining Ionization Equilibria in Proteins; Combinatorial Problem; Cooperative Ionization; Allocation Variation of Polar Hydrogen Atoms; Examples for pH-Dependent Hydrogen Bonding; Conformational Flexibility Involving Non-Hydrogen Atoms; Unfolding Induced by pH; Modeling of Unfolded Proteins; Thermal Stability of Proteins.

Product Details

  • ISBN13: 9781860947070
  • Format: Hardback
  • Number Of Pages: 348
  • ID: 9781860947070
  • ISBN10: 1860947077

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