This book is a comprehensive guide to occupational factors of malignant diseases. It discusses potentially work-related malignancies, in the context of exposure assessment, specific clinical and pathological features of occupational cancer and biomarkers of exposure and disease. Epidemiological data about risk ratios of the cancer in question are reviewed for various occupations and with exposure to specific carcinogens, carcinogenic mechanisms, host susceptibility factors (genetic and other) and other environmental and life-style risk factors. Aspects such as surveillance of workers exposed to carcinogens and strategies for prevention of occupational cancer are also discussed.
Occupational Cancers is aimed at oncologists, pathologists, residents in training, clinical researchers, clinicians in occupational health, epidemiologists, pulmonologists, lawyers and public health officials.
Paolo Boffetta, MD, MPH Bluhdorn Professor of International Community Medicine Director, Institute for Translational Epidemiology Associate Director for Population Sciences, Tisch Cancer Institute Icahn School of Medicine at Mount Sinai One Gustave L. Levy Place New York, NY, USA Sisko Anttila MD, PhD Helsinki University Central Hospital, Hospital District of Helsinki and Uusimaa, Laboratory Services, HUSLAB, and Finnish Institute of Occupational Health, Helsinki, Finland.
Historical Overview of Occupational Cancer Research.- Genetics and Gene-Environment Interactions.- Mechanisms of Environmental and Occupational Carcinogenesis.- Cancer of the Oral Cavity, Pharynx and Nasopharynx.- Pancreatic Cancer.- Cancers of the Intestine, Liver and Biliary Tract.- Sinonasal Cancer.- Laryngeal Cancer.- Lung cancer (exposure assessment, pathology, epidemiology).- Lung Cancer: Mechanisms of Carcinogenesis.- Lung Cancer: Genetic Susceptibility.- Lung Cancer: Molecular Markers.- Malignant Mesothelioma: Epidemiology.- Malignant Mesothelioma: Clinical and Imaging Findings.- Malignant Mesothelioma: Asbestos Exposure.- Malignant Mesothelioma: Pathology.- Malignant Mesothelioma: Mechanism of Carcinogenesis.- Malignant Mesothelioma: Genetic Susceptibility.- Malignant Mesothelioma: Molecular Markers.- Neoplasm of Soft Tissues.- Malignant Neoplasms of the Skin.- Breast Cancer.- Malignant Tumors of the Female Reproductive System.- Malignant Tumors of the Male Reproductive System.- Kidney Cancer.- Bladder Cancer.- Malignant Tumors of the Central Nervous System.- Lymphohematopoietic Malignancies.- Occupational Cancer Burden.- Occupational Carcinogens and Cancer in Children.- Strategies for Primary Prevention of Occupational Cancer.- Screening for Occupational Cancer.- Role of Registers in Occupational Cancer Control.- Appendix I Questionnaire on Exposure to Asbestos.