Pharmacogenomics in Clinical Therapeutics

Pharmacogenomics in Clinical Therapeutics

By: Amitava DasGupta (editor), Loralie J. Langman (editor)Hardback

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Pharmacogenomics is the process of analyzing patients' genes to predict the onset of adverse reactions or forecast the effectiveness of therapeutic drugs. This useful text is written to discuss both the theory and the clinical application of the principles of pharmacogenomics. Current research has clearly established that a range of treatments may be greatly improved through genetic profiling of individual patients before certain therapies begin. Aimed at clinicians, pharmacologists, and clinical laboratory professionals this book discusses the important role of laboratory tests in the practice of personalized medicine. An important new book, Pharmacogenomics in Clinical Therapeutics serves as a guide to the basic principles of pharmacogenomics in a range of common therapeutic areas and as the basis of the personalized medicine of the future.

About Author

Amitava Dasgupta, Ph.D, DABCC, FACB, Professor of Pathology and Laboratory Medicine, University of Texas Health Sciences Center at Houston, Houston, TX. Loralie J. Langman, Ph.D, DABCC, FACB, Associate Professor of Laboratory Medicine, Mayo Clinic, Rochester, MN.


List of Contributors, vii Preface, ix 1 Pharmacogenomics Principles: Introduction to Personalized Medicine, 1 Parvaz Madadi, PhD and Gideon Koren, MD 2 Traditional Therapeutic Drug Monitoring and Pharmacogenomics: Are They Complementary? 15 Christine L.H. Snozek, PhD, Loralie J. Langman, PhD, and Amitava Dasgupta, Ph.D 3 Pharmacogenomics Aspect of Warfarin Therapy, 26 Matthew D. Krasowski, MD, PhD 4 Pharmacogenetics and Cancer Chemotherapy, 39 Christine L.H. Snozek 5 Pharmacogenomic Considerations in Anesthesia and Pain Management, 53 Christine M. Formea, PharmD and Wayne T. Nicholson, MD, PharmD 6 Pharmacogenomics of Immunosuppressants, 70 Nicolas Picard, PharmD, PhD and Pierre Marquet, MD, PhD 7 Pharmacogenomics of Cardiovascular Drugs, 98 Linnea M. Baudhuin, PhD 8 Pharmacogenomic Aspects of Antiretroviral Therapy, 127 Natella Y. Rakhmanina, MD, PhD and John N. van den Anker, MD, PhD 9 Pharmacogenetics of Psychoactive Drugs, 144 Jorge L. Sepulveda, MD, PhD 10 Pharmacogenomic Aspects of Adverse Drug Drug Interactions, 176 Loralie J. Langman, PhD and Christine L.H. Snozek, PhD 11 Microarray Technology and Other Methods in Pharmacogenomics Testing, 185 Jorge L. Sepulveda, MD, PhD 12 Pharmacogenetic Testing in the Clinical Laboratory Environment, 201 Mark P. Borgman, PhD and Mark W. Linder, PhD Index, 225

Product Details

  • ISBN13: 9780470657348
  • Format: Hardback
  • Number Of Pages: 256
  • ID: 9780470657348
  • weight: 686
  • ISBN10: 0470657340

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